Mycophenolic acid

Mycophenolic acid

• Classification: Organ Transplant Medicine

Mycophenolic Acid?

It is immune-suppressant medicine to reduce the organ rejection during transplant.

Mycophenolic acid oral uses -

• Prophylaxis for organ transplant.
• Post-transplant therapy -
• Kidney transplant
• Liver transplant
• Heart transplant
• Autoimmune diseases- Psoriasis, SLE (off-label)

Working of Mycophenolic Acid?

• It down-regulates the activity of B cells and T cells.
• Suppress the immune system.
• Helps prevent rejection of the new organ when transplanted in the body.
• Reduces anaphylactic immune response.

Common side effects

• Skin rashes
• Risk of infection
• Low blood count
• Low platelets
• Anemia

Serious side effects

• Risk of severe infection
• Bleeding - gastrointestinal perforation and bleeding
• Inflammation in the colon
• Risk of cancers, lymphomas, and skin cancers
• Risk of brain infection

Benefits:

• More selective action, target immune cells.
• Do not harm other cells.
• Reduces the need for steroids
• Minimizes the risk of rejection
• Maintain immune tolerance
• Supports long-term graft survival

Precautions:

• To be used cautiously in
• Kidney impairment
• Bleeding disorders
• Active infection
• Underline cancer
• Leukemia
• Elderly patients

Safety instructions

Maintain contraception during the treatment.

Due to a compromised immune system avoid taking live medicines.

Contraindications

• Should not be used in pregnant women and breastfeeding mothers.
• Hypersensitivity or allergy to drug components.

Warnings

• To be used under medical prescription.
• Drug Interactions
• Antiviral
• Antacids
• Antibiotics
• And other immune suppressants

Important Monitoring Considerations

• Monitor for -
• Total blood count
• Liver and kidney functions

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