Abacavir 600mg + Lamivudine 300mg

Abacavir + Lamivudine

Classification: HIV medicine

What is Abacavir + Lamivudine?

It is a fixed-dose combination used for HIV – 1 treatment. Used as an adjuvant to other antiretrovirals.

Uses of Abacavir, Lamivudine Combination

• • To treat HIV -1 infections

How does it work?

• • The drug combination works by inhibiting viral replication and multiplication.
• • Terminates DNA chain elongation
• • Causes cell death

Benefits

• • Significantly lowers viral load
• • Improves immunity
• • Inhibit transmission
• • Delays disease progression

Common Side Effects

• • Nausea
• • GIT upset
• • Reduced appetite
• • Insomnia
• • Diarrhea
• • Skin rashes

Serious Side Effects

• • Fatty liver – enlarged liver size
• • Liver toxicity
• • Lactic acidosis
• • Pancreatitis
• • Allergic reaction

Precautions of Abacavir + Lamivudine

To be cautiously used in people –

• • Liver disorders
• • Co-infections
• • Kidney impairment
• • Cardiovascular disorder
• • Alcohol use due to liver toxicity
• • Pregnant and breastfeeding women

Contraindications

• • Severe liver dysfunction
• • Hypersensitivity or allergy to drug components

Warnings

To be used under medical prescription.

Hepatitis B co-infections may cause serious viral flare-ups; do not stop medication immediately.

Important Monitoring Considerations

Check for –

• • Lactic acidosis
• • Liver function – elevated liver enzymes
• • Viral loads (HIV, HBV)
• • Pancreatitis

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