Description
Qurled 400 mg (Sofosbuvir) is an anti-viral drug indicated against chronic hepatitis C (HCV) infection with genotype 1-4. Sofosbuvir is known for its direct-acting antiviral (DAA) properties, inhibiting non-structural protein 5B (NS5B) protein, a special type of protein responsible for multiplication (RNA replication and virion assembly) of viral cells.
For achieving a sustained virologic response (SVR), sofosbuvir is used with other anti-HCV agents assisting in,
- • Reduction of damages associated with liver
- • Improvement in the quality of life of patients
- • Liver cancer incidence
Administration of Qurled 400 mg (Sofosbuvir):
Qurled 400 mg (Sofosbuvir) is administered orally once in a form of 400 mg dose taken with or without food. In addition, either ribavirin alone or ribavirin plus pegylated interferon is also recommended.
Note: Both pros and cons should be taken into consideration before increasing the duration of treatment.
Once swallowed, sofosbuvir is absorbed (bio-available) in between 30 mins to 2 hours with a binding affinity of 61-65% with viral cells. It is generally metabolized in the liver and after its activities, more than 50% of the drug is excreted from the body in between 40 minutes to 27 hours.
When should Hepcinat 400 (Sofosbuvir) be avoided or used cautiously?
Interactions with other drugs:
If patients were taking other drugs before or along with sofosbuvir,
- • The efficacy gets comprised
- • Dosages need to be modified
- • Shows a higher rate of side-effects
Other warning signs:
If patients are suffering from or had,
- • History of Hepatitis B viral infection before taking sofosbuvir.
- • Liver transplant before the initiation of dosage
- • Complications in the liver other than HCV infection
- • Heart problems
- • Kidney disease or undergoing dialysis
- • HIV infection
- • Other severe medical condition
Issues during childbirth if patients,
- • Are pregnant or planning to get pregnant
- • Are male and your partner is planning to get pregnant
- • Are breastfeeding or planning to breastfeed
Side-effects of Qurled 400 mg (Sofosbuvir):
Sofosbuvir has a reasonable safety profile with minimal side-effects. Due to its safety profile, it has a therapeutic advantage over other anti-HCV agents like the absence of low red blood cell (RBC) count (anemia) and neuropsychiatric effects.
Serious side-effects: Slow heart rate (bradycardia)
Side-effects in combination with ribavirin:
- • Headache
- • Tiredness (Fatigue)
Side-effects in combination with ribavirin and pegylated interferon:
- • Lack of sleep (Insomnia)
- • Nausea
- • Tiredness (Fatigue)
- • Headache
Uncommon side-effects:
- • Pain in the muscles (Myalgia)
- • Physical weakness (Asthenia)
- • Skin itchiness (Pruritis)
- • Diarrhea
- • Severe rashes on the skin
- • Fever
- • Chills
- • Low consumption of diet
Note: These are not all possible side-effects of Qurdac 400 mg (Sofosbuvir), please ask your doctor for more information regarding the same.
