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Tudobest (Tenofovir disoproxil fumarate 300 mg) is an anti-HIV-1 and HBV drug indicated in adults and children over 2 years of age weighing at least 35 kgs. Irrespective of the type of infection, Tudobest (Tenofovir disoproxil fumarate 300 mg) is administered orally once daily without food.
Tudobest (Tenofovir disoproxil fumarate 300 mg) is capable of preventing the duplication of viral cells by hindering the replication process. It allows fumarate to control the infection and boost our immune system. Even though the combined activity does not cure HIV-1 infection at will yet it improves the quality of life of such patients. However, before starting Tudobest (tenofovir disoproxil fumarate 300 mg), all HBV infected patients should be tested for HIV antibodies.
Modified dosing in patients with kidney (renal) impairment:
- Mild (Creatine Clearance: 50-80 mL/min): Dosage adjustment is not recommended
- Moderate (Creatine Clearance: 50 or greater mL/min): 1 tablet of 300 mg every 24 hours
- Moderate renal impairment (Creatine Clearance: 30-49 mL/min): 1 tablet of 300 mg every 48 hours
- Severe (Creatine Clearance: 10-29 mL/min): 1 tablet of 300 mg every 72 to 96 hours
- Hemodialysis: 1 tablet of 300 mg every 7 days or after completing the dialysis cycle
Note: Creatinine clearance test: Used for checking the functioning of the kidney
Precautions and warnings associated with Tudobest (Tenofovir disoproxil fumarate 300 mg):
| Associated condition | Description | Cause of the problem | Associated symptoms |
| Immune Reconstitution Syndrome | Inapparent changes in the immune system | Other anti-HIV medicines | – |
| Severe liver complications | – | HIV and HBV coinfection | Yellow-colored eyes, dark colored urine, loss of appetite, nausea, or pain in the abdomen |
| Kidney dysfunctions: Acute renal failure & Fanconi syndrome | Extreme disposal of biomolecules e.g. glucose through urine | Nephrotoxic drugs | – |
| Bone loss and mineralization defects | Decrease in bone mineral density | Bone fractures or osteopenia | Bone pain, softening of bones, or thin bones |
| Lactic acidosis | Excessive amount of lactic acid in the blood | – | Unusual weakness, pain in the muscles, slow or fast breathing, stomach pain with vomiting/nausea, cold hands and feet, dizziness, or abnormal heartbeats |
Side-effects of Tudobest (Tenofovir disoproxil fumarate 300 mg):
Tudobest 300 mg (tenofovir disoproxil fumarate) has a reasonable safety profile with a low occurrence of side-effects. Based on the type of infection, the side-effects of the drug have been mentioned in the table below.
| HIV-infected adults and children | Advanced HBV infections |
| Rashes on skin | Abdominal pain |
| Diarrhea | Itching |
| Depression | Fever |
| Weakness | Difficulty in sleeping and dizziness |
| Nausea | Nausea |
| Vomiting |
Note: Tudobest (tenofovir disoproxil fumarate 300 mg) may depict other side-effects too, consult your doctor for specialized medical advice for the same.
Tudobest (tenofovir disoproxil fumarate 300 mg) is also available in these countries: (South East Asia, South America, Eastern Europe, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Macedonia, Poland, Republic of Kosovo, Republic of Moldova, Romania, Russia, Serbia, Slovak Republic, Slovenia, Malaysia, Indonesia, Philippines, Venezuela and Korea.) and many more…
Ramill Youhana –
Tudobest (Tenofovir disoproxil fumarate 300 mg) is very effective anti-HIV-1 and anti-HBV medicine.
Reginald Prepetit –
Tudobest can stop viral cells from duplicating by interfering with the replication process.