Tudobest

Tudobest (Tenofovir disoproxil fumarate 300 mg) is an anti-HIV-1 and HBV drug indicated in adults and children over 2 years of age weighing at least 35 kgs. Irrespective of the type of infection, Tudobest (Tenofovir disoproxil fumarate 300 mg) is administered orally once daily without food.

Tudobest (Tenofovir disoproxil fumarate 300 mg) is capable of preventing the duplication of viral cells by hindering the replication process. It allows fumarate to control the infection and boost our immune system. Even though the combined activity does not cure HIV-1 infection at will yet it improves the quality of life of such patients. However, before starting Tudobest (tenofovir disoproxil fumarate 300 mg), all HBV infected patients should be tested for HIV antibodies.

Modified dosing in patients with kidney (renal) impairment:

• Mild (Creatine Clearance: 50-80 mL/min): Dosage adjustment is not recommended
• Moderate (Creatine Clearance: 50 or greater mL/min): 1 tablet of 300 mg every 24 hours
• Moderate renal impairment (Creatine Clearance: 30-49 mL/min): 1 tablet of 300 mg every 48 hours
• Severe (Creatine Clearance: 10-29 mL/min): 1 tablet of 300 mg every 72 to 96 hours
• Hemodialysis: 1 tablet of 300 mg every 7 days or after completing the dialysis cycle

Note: Creatinine clearance test: Used for checking the functioning of the kidney

Precautions and warnings associated with Tudobest (Tenofovir disoproxil fumarate 300 mg):

Associated condition	Description	Cause of the problem	Associated symptoms
Immune Reconstitution Syndrome	Inapparent changes in the immune system	Other anti-HIV medicines	–
Severe liver complications	–	HIV and HBV coinfection	Yellow-colored eyes, dark colored urine, loss of appetite, nausea, or pain in the abdomen
Kidney dysfunctions: Acute renal failure & Fanconi syndrome	Extreme disposal of biomolecules e.g. glucose through urine	Nephrotoxic drugs	–
Bone loss and mineralization defects	Decrease in bone mineral density	Bone fractures or osteopenia	Bone pain, softening of bones, or thin bones
Lactic acidosis	Excessive amount of lactic acid in the blood	–	Unusual weakness, pain in the muscles, slow or fast breathing, stomach pain with vomiting/nausea, cold hands and feet, dizziness, or abnormal heartbeats

Side-effects of Tudobest (Tenofovir disoproxil fumarate 300 mg):

Tudobest 300 mg (tenofovir disoproxil fumarate) has a reasonable safety profile with a low occurrence of side-effects. Based on the type of infection, the side-effects of the drug have been mentioned in the table below.

HIV-infected adults and children	Advanced HBV infections
Rashes on skin	Abdominal pain
Diarrhea	Itching
Depression	Fever
Weakness	Difficulty in sleeping and dizziness
Nausea	Nausea
	Vomiting

Note: Tudobest (tenofovir disoproxil fumarate 300 mg) may depict other side-effects too, consult your doctor for specialized medical advice for the same.

Tudobest (tenofovir disoproxil fumarate 300 mg) is also available in these countries: (South East Asia, South America, Eastern Europe, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Macedonia, Poland, Republic of Kosovo, Republic of Moldova, Romania, Russia, Serbia, Slovak Republic, Slovenia, Malaysia, Indonesia, Philippines, Venezuela and Korea.) and many more…