Description
Velakast (sofosbuvir 400mg + velpatasvir 100mg) is a fixed-dose combination (FDC) drug used in patients with chronic hepatitis C viral (HCV) infection with genotype 1 to 6 in adults. With 93-99% of response against HCV cells depending on the genotype and the levels of cirrhosis, the FDC drug in a combined-action reduces the multiplication of HCV cells.
Sofosbuvir inhibits NS5B protein whereas velpatasvir inhibits NS5A protein. These proteins help in the replication process and their inhibition ensures that viral toll on the body is lessened.
Velakast (sofosbuvir + velpatasvir) is taken in a form an FDC i.e. 1 tablet (sofosbuvir + velpatasvir combination) once daily for 12 weeks. It is taken orally and the dose is not limited to the food consumption.
Side-effects of Velakast (sofosbuvir 400mg + velpatasvir 100mg):
With their decent safety profile, the FDC combination is deemed to have more benefits over other anti-HCV combinational drugs. The side-effects are minor with headache and tiredness (Fatigue) being the most common ones whereas skin rashes and depression are the uncommon ones.
Serious side-effects: Slow heart rate (bradycardia)
Other side-effects:
Based on the disease type and individuals, the side-effects of Velakast (sofosbuvir + velpatasvir) may differ. The table below shows side-effects other than the above-mentioned common ones.
| Cirrhosis with a functional system | Without cirrhosis or with compensated cirrhosis |
| Low red blood cell count (Anemia) | Nausea |
| Lack of sleep (Insomnia) | Physical weakness (Asthenia) |
| Diarrhea | Lack of sleep (Insomnia) |
| Nausea | – |
Note: These are not all possible side-effects of Velakast (sofosbuvir 400mg + velpatasvir 100mg), please ask your doctor for more information regarding the same.
Warnings associated with Velakast (sofosbuvir + velpatasvir):
Problems related to liver
- HCV patients should be checked for Hepatitis B viral infection if found velakast (sofosbuvir + velpatasvir) should be immediately stopped
- Other liver problems in association with HCV infection should be taken into consideration and accordingly, the dosage should be modified or restricted
Other issues:
- Patients should be mention if they are suffering from any sort of kidney disease or undergoing dialysis, modification of dosage is required in such cases
- Other severe medical conditions related to heart and brain
Pregnancy-related issues:
If patients are,
- Pregnant or planning to get pregnant
- Breastfeeding or planning to breastfeed
- Male and the partner want to get pregnant (Avoid intercourse without condoms for at least 6 months after the therapy)
Note: We are also exporting to countries: Malaysia, Indonesia, Philippines, Venezuela and Korea.
The common side effects of taking Velakast are:
- Fatigue
- Headache
- Weight loss
- Diarrhea
- Skin rashes
- Irritability
All these are very common side effects and can be cured easily. Always inform your doctor about the severe side effects.
The serious side effects of taking Velakast are
- Slowing down of heart rate
- Lack of sleep
Seek medical aid at the earliest to avoid other health issues.This medicine should be taken orally with food or as prescribed by the doctor. Do not chew or crush the medicine. Swallow with water and follow the dosage regularly for an effective treatment.
Some precautions to be taken are:
- Make sure to take plenty of rest and eat nutritious food.
- Inform your doctor about your previous medical history
- Inform your doctor about certain allergies and other common side effects.
- Avoid driving and consumption of alcohol.
- Avoid indulging in sexual activities.
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