Abacavir, Dolutegravir, Lamivudine

Classification: HIV medicine

What is Abacavir, Dolutegravir, and Lamivudine combination?

The combination of the drug in a fixed proportion is used for HIV-1 treatment.
Used in children and young adults.

Uses

  • • First-line treatment for HIV infection
  • • Preventive or maintenance therapy of HIV

How does the combination work?

  • • It stops viral cell multiplication and replication.
  • • Reduces HIV amount in the blood

Benefits

  • • Potent viral suppression to undetectable levels
  • • Convenient daily dosing
  • • Lowers resistance
  • • Better tolerance and adherence
  • • Easy convenient use
  • • Improves the immune system

Common side effects

  • • Headache
  • • Skin rashes
  • • Insomnia
  • • Muscle pain
  • • Joint pain
  • • GIT upset
  • • Fever
  • • Anxiety, mood changes

Serious side effects

  • • Overactive immune system
  • • Hepatitis B flare
  • • Severe allergy
  • • Skin peeling
  • • Liver toxicity
  • • Severe anxiety, suicidal thoughts, and insomnia

Precautions

To be used cautiously in:

  • • Elderly persons
  • • Co-infection – hepatitis B
  • • Renal impairment
  • • Liver dysfunction
  • • Cardiovascular disorders
  • • Neurological disorders
  • • Pregnant and breastfeeding women

Contraindications

  • • Severe liver dysfunction
  • • Hypersensitivity or allergy to drug components

Warnings

To be used under medical prescription.
Hepatitis B co-infections may cause serious viral flare-ups; do not stop medication immediately.

Important Monitoring Considerations

Check for –

  • • Lactic acidosis
  • • Liver function – elevated liver enzymes
  • • Viral loads (HIV, HBV)
  • • Neurological conditions
  • • CD4 cell count
  • • Cardiovascular functions

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