Bortezomib

Classification: Anticancer medicine

What is Bortezomib?

It is an anticancer medicine for IV or Subcutaneous administration.

Uses of Bortezomib

  • Newly diagnosed with myeloma
  • Relapsed myeloma
  • Mantle cell lymphoma

How does it work?

  • It inhibits the repair mechanisms
  • Causes the accumulation of toxic proteins
  • Disrupts DNA signaling
  • Causes cancer cell death

Common Side Effects

  • Tiredness
  • Reduced appetite
  • Neuropathy
  • Fever
  • Skin rashes
  • Dizziness
  • Insomnia
  • Headache
  • Delays wound healing

Serious Side Effects

  • Bone marrow suppression
  • Respiratory distress
  • Risk of severe infections
  • Severe bleeding
  • Hepatic toxicity
  • Low blood pressure
  • Heart complications – arrhythmia
  • Severely low blood pressure
  • Electrolyte imbalance

Precautions

To be used cautiously in

  • Elderly patients
  • Neuropathic condition
  • Cardiovascular disease
  • Low blood pressure
  • Immune-compromised individuals
  • Ongoing surgery
  • Liver disorders

Contraindications

Not to be used in patients-

  • Hypersensitivity or allergy to the drug composition
  • Pregnant and breastfeeding
  • Severe liver disorders
  • Active infections

Warnings

Prescription drug to be used under medical supervision.

Important safety and monitoring information

  • Kidney functions
  • Liver functions
  • Total blood count
  • Early signs of neuropathy
  • Blood pressure
  • Infections
  • Hydration
  • Neurological symptoms – anxiety, confusion
  • Chest pain

Storage

To be stored at 2-8 degrees Celsius.

To be protected from light.

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