Bosentan 125mg

Classification: Pulmonary Hypertension Medicine

Bosentan?

Bosentan used against pulmonary hypertension, is a hypertensive medicine.

Uses of Bosentan

  • • Arterial hypertension
  • • Ulcers in systemic sclerosis

Off-label uses

  • • Thromboembolic hypertension (off-label)
  • • Congenital pulmonary hypertension
  • • Systemic sclerosis (Raynaud’s phenomenon)

Working of Bosentan

  • • It relaxes the blood vessels
  • • Blocks the natural vasoconstrictor in blood
  • • It dilates the blood vessels and reduces blood pressure in the lungs.

Benefits

  • • Its helps the heart to pump efficiently
  • • Lowers lung pressure
  • • Improves blood flow
  • • Improves breathing
  • • Enhances exercise tolerance
  • • Slows disease progression
  • • Prevents ulcers in scleroderma

Common Side Effects

  • • Headache
  • • Flushing of the skin
  • • Redness of the skin
  • • Fluid retention in ankles, legs
  • • Basal congestion
  • • Tiredness
  • • Diarrhea
  • • Bronchitis
  • • Muscular pain and joint pain

Serious Side Effects

  • • Liver damage – increased liver enzymes
  • • Dark urine, yellowish urine
  • • Serious fluid retention – weight gain, leg swelling
  • • Decreased sperm count

Precautions

To be cautiously used in patients with –

  • • Liver disorders
  • • Low blood count
  • • Fluid retention
  • • Cardiac failure
  • • Impaired sperm production in men

Contraindications

Not to be used in patients-

  • • Allergy to the drug components
  • • Pregnant and breastfeeding women
  • • Severe liver disorders

Warnings

Prescription drug to be used under medical supervision.

Drug Interactions

Use of Bosentan is contraindicated with:

  • • Cyclosporine
  • • Hormonal contraceptives
  • • Antibiotics
  • • Antifungals
  • • Antivirals
  • • Statins
  • • ED medicines
  • • Anticoagulants

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