Fulvestrant

Classification: Anticancer Medicine

Fulvestrant?

It is an anticancer medicine widely used for breast cancer in post-menopausal women.

Uses

  • • HER-2 positive breast cancer
  • • HER-2 negative breast cancer
  • • Breast cancer that is resistant to endocrine therapy

How does Fulvestrant work?

  • • Selective Estrogen Receptor Antagonist.
  • • It inhibits the estrogen hormone, which causes cancer cells to grow.
  • • Stops cancer cell growth
  • • Shrinks the tumor.

Benefits

  • • As a preferred second-line option.
  • • Longer progression–free survival
  • • Directly downregulates the receptor for complete blockade
  • • Has better tolerance and a favorable safety profile.

Precautions

Carefully administer to patients with:

  • • Blood disorders
  • • Hypersensitive individuals
  • • Hepatic impairment
  • • Children, pregnant or lactating mothers
  • • Elderly patients who are at risk of osteoporosis.
  • • Vitamin D or Calcium deficiency

Adverse Drug Effects

  • • Risk of bleeding
  • • Sore throat
  • • Mouth sores
  • • Upset stomach,
  • • Nausea,
  • • Loss of appetite
  • • Headache,
  • • Tiredness
  • • Flushing or redness of the skin at the site of injection.

Serious Side Effects

  • • Hepatotoxicity – yellow coloration of urine, jaundice, hepatitis
  • • Pulmonary embolism, blood clots
  • • Severe necrosis
  • • Gastrointestinal perforation, bleeding
  • • Fracture or risk of bone demineralization

Important Safety and Monitoring Information

To monitor regularly during the therapy

  • • Total blood count
  • • Hepatic functions
  • • Kidney functions
  • • Risks of bleeding
  • • Thromboembolic events
  • • Local tissue necrosis

Contraindications

  • • Allergy or hypersensitivity to drug components
  • • Breastfeeding mothers
  • • Pregnant women

Warning

To be used under the medical supervision of an oncology specialist.

Storage

It is to be stored at 2-8 degrees Celsius, protected from light.

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