Imatinib
Classification: Anticancer
Imatinib Mesylate?
It is a targeted anticancer treatment used against various blood cancers and bone marrow cancers.
Uses of Imatinib
- • Chronic myeloid leukemia
- • Myeloproliferative disease
- • Lymphoblastic leukemia
- • Gastrointestinal tumors
- • Philadelphia Chromosome–Positive leukemia
How Does Imatinib Work?
It blocks cell multiplication and division. Blocks rapidly dividing cells.
Common Side Effects
- • Fluid retention
- • Skin rash
- • Headache
- • Indigestion – nausea, diarrhea
- • Abdominal pain
- • Loss of appetite
- • Muscle pain, joint pain
- • Anemia
Serious Side Effects
- • Hepatic-toxicity – jaundice, hepatitis
- • Heart issues – irregular heartbeat, arrhythmias
- • Shortness of breath
- • Bone marrow suppression
- • Perforation in the gastrointestinal wall
- • Severe rash or peeling of the skin
Precautions
To be used cautiously in patients with –
- • Kidney disorders
- • Liver disorders
- • Cardiac insufficiencies
- • Thyroid disease
Contraindications
- • Allergy or hypersensitivity to Imatinib or its components
- • Breastfeeding mothers
- • Pregnant women
- • Congestive heart failure
Important Safety and Monitoring Information
Regularly monitor-
- • Liver functions
- • Blood count
- • Weight and swelling in the body
- • Pleural/pericardial effusion or pulmonary edema
- • Cardiac functions – ECG/ECHO
- • Thyroid functions – TSH/T4 Levels
Important Drug Interactions
Monitor closely or consider dose reduction when co-administered with:
- • Antifungals
- • Macrolides
- • Warfarin
- • Statins
- • Rifampin-like drugs
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