L Asparaginase Injection 10000 IU

Classification – Anti-cancer medicine

L-Asparaginase?

Asparaginase is an enzyme used as an anticancer medicine that blocks the cancer processes of growth and division.
It is the targeted therapy drug that kills the viable cells without harming the normal cells.
It is used to achieve complete remission in adults and pediatric patients.

Uses of Asparaginase –

  • • Lymphoblastic Leukemia (acute) / lymphoma

Working of Asparaginase-

  • • Break down the L-asparagine enzyme
  • • Cancer cell starvation
  • • Apoptosis and cell death

Common side effects of Asparaginase

  • • Increases infection risks
  • • Blood clots
  • • Diarrheas
  • • Weight loss
  • • Loss of appetite
  • • High albumin levels, bilirubin levels
  • • Edema
  • • Lowered blood pressure
  • • Abdominal pain

Serious Side-effects

  • • Pancreatic bleeding
  • • Thromboembolism- clots and strokes
  • • Bone marrow suppression – thrombocytopenia
  • • Shortness of breath
  • • Toxicities
  • • Hepatotoxicity
  • • Thrombosis and bleeding
  • • Pancreatitis

Contraindications

  • • Not to be used in hypersensitivity to drug components
  • • Breastfeeding mothers
  • • Pregnant women

Precautions

To be used cautiously in patients with

  • • Heart disease
  • • Low blood count
  • • Liver disease
  • • Pancreatitis

Warnings

To be used under medical supervision only, do not mix dextrose-containing solutions (incompatibility).

Storage

  • • Store at 2-8 degrees Celsius
  • • Reconstitute the solution just before administration

Important safety and monitoring information

Regular monitoring is required for liver functions, pancreatic enzymes, blood coagulation, and sugar levels.

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