Ledipasvir- 90mg + Sofosbuvir- 400mg

Composition

  • Ledipasvir – 90 mg
  • Sofosbuvir – 400 mg

Classification: Hepatitis C Medicine

Ledipasvir, Sofosbuvir combination?

It is a combination of drug therapy used for hepatitis C infection for genotypes -1, 4, 5, and 6.

Uses

  • Chronic hepatitis C
  • Post liver transplant hepatitis C prevention

Working of Ledipasvir and Sofosbuvir combination

The combination of two drugs inhibits two different enzymes and offers a potential blockade for viral replication.

Common Side Effects

  • Tiredness
  • Insomnia
  • Diarrhea
  • Nausea
  • Headache
  • Irritable mood

Serious Side Effects

  • Slow heart rate
  • Skin rashes
  • Swelling
  • Difficulty in breathing
  • Reactivation of hepatitis B
  • Liver dysfunction
  • Reduce hemoglobin count when used with ribavirin

Benefits

  • Can be used in pediatric patients
  • Can be used in compensated cirrhosis
  • Can be used post-liver transplant
  • Well-tolerated
  • Safe and effective in HIV co-infections

Precautions

To be used cautiously in patients

  • Hepatitis B co-infections
  • HIV co-infections
  • Heart disorders
  • Liver disorders
  • Pregnant and breastfeeding women
  • In children
  • Kidney disorders

Contraindications

  • Allergy or hypersensitivity to drug components
  • End-stage renal disease
  • Combined use with Amiodarone
  • In pregnancy, when combined with ribavirin

Warning

It is a prescription drug to be taken under medical supervision only.

Important Safety and Monitoring Information

  • Regular monitoring of hepatic functions
  • Renal functions
  • Cardiac functions
  • Co-infections
  • Neuropsychiatric adverse reactions
  • Drug interactions – Ribavirin and Amiodarone
  • Not to be used alone for HCV infections

Drug Interactions

  • Ribavirin
  • Antacids
  • Rifampin
  • Histamine blockers
  • Proton pump inhibitors
  • Anticoagulants

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