Letrozole

Classification: Anticancer

What is Letrozole?

It is an anticancer medicine, used for hormone-sensitive breast tumors.

Uses of Letrozole

  • Breast cancer
  • PCOS (off-label)

Working of Letrozole

  • It reduces estrogen levels
  • Inhibits estrogen-sensitive cancer cell growth and proliferation

Common Side Effects

  • Hot flashes
  • Muscle pain
  • Dizziness
  • Night sweating
  • Tiredness

Serious Side Effects

  • Bone weakening and thinning
  • Mood changes
  • Severe depression
  • Increased risk of fractures
  • Increased cholesterol
  • Bleeding

Important Monitoring Instructions:

  • Liver functions
  • Bone density
  • Cholesterol levels
  • Cognitive functions
  • Hormonal levels

Safety Note

  • Maintain calcium and vitamin D through supplements
  • Avoid alcohol and smoking to prevent bone loss
  • Avoid pregnancy during the treatment

Precautions

To be cautiously used in –

  • Liver impairment
  • Cardiovascular diseases
  • High cholesterol
  • Risk of thromboembolism
  • Weak bones or risk of osteoporosis

Contraindications

  • Should not be used in pregnant women and breastfeeding mothers
  • Hypersensitivity or allergy to drug components
  • Premenopausal women

Warnings

To be used under medical prescription.

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