Lopinavir / Ritonavir

Classification – HIV medicine

Why Lopinavir/ Ritonavir combination?

A fixed-dose combination, widely used against HIV infection.
Lopinavir induces viral cell death, and ritonavir prolongs its effect.

Uses of Lopinavir/Ritonavir

  • • HIV infection

Working of the Lopinavir-Ritonavir Combination

  • • It inhibits the HIV protease enzyme
  • • Inhibits cell multiplication and replication
  • • Causes viral cell death

Benefits

  • • It significantly lowers the viral load.
  • • Improves immune function
  • • Increases CD-4 cell count

Common Side Effects

  • • Nausea
  • • Vomiting
  • • Tiredness
  • • Increased cholesterol levels
  • • Increased blood sugar
  • • Headache
  • • Rash, itchiness

Serious Side Effects

  • • Hepatotoxicity – elevated liver enzymes
  • • QT prolongation
  • • Severe heart complications
  • • Lactic acid buildup
  • • Pancreatitis
  • • Allergic reaction

Precautions

To be used cautiously in:

  • • Severe liver disorders
  • • Renal impairment
  • • Cardiovascular diseases
  • • High cholesterol levels
  • • Pancreatitis
  • • Bleeding disorders
  • • Elderly
  • • Children
  • • Pregnant and breastfeeding women

Important Monitoring Considerations

  • • Liver functions
  • • Kidney functions
  • • Blood sugar and blood pressure
  • • Signs of pancreatitis

Drug Interactions

Dose adjustment is required when used with:

  • • Anticonvulsant drugs
  • • Cardiovascular drugs
  • • Antihypertensives
  • • Anti-fungal and
  • • Anti-tubercular drugs
  • • Cholesterol-lowering medicines – statins
  • • Various herbal formulations – ergotamine derivatives
  • • Sedatives

Contraindications

  • • Severe liver dysfunction
  • • Hypersensitivity or allergic reaction to the drug or its excipients

Warnings

To be used under medical prescription. Do not stop in Hepatitis B patients.

Gandhi Medicos – Trusted Pharmacy for HIV Medicine

  • ✔ WHO-GMP Certified – Adhering to the highest global standards of safety and quality.
  • ✔ 100% Authentic, Verified Products – Original packaging, verified batch numbers, and secure labeling.
  • ✔ 2,500+ Satisfied Clients – Including hospitals, clinics, and individual customers worldwide.
  • ✔ 3,000+ Monthly Deliveries – Ensuring timely access to life-saving HIV therapeutics.
  • ✔ Temperature-Controlled Shipments – Safeguarding medicine integrity across long distances.
  • ✔ Global Reach – Seamless delivery network spanning over 50 countries, including CIS nations, Africa, Southeast Asia, and South America.