Mycophenolate Mofetil

Classification: Organ Transplant Medicine

Mycophenolate Mofetil?

It is used to suppress immune system, reduce organ rejection in organ transplant.

Uses of Mycophenolate Mofetil

  • Prophylaxis for organ transplant
  • Post-transplant therapy – Kidney, Liver, Heart transplant
  • Autoimmune diseases – rheumatoid arthritis

Common side effects

  • Skin rashes
  • Risk of infection
  • Low blood count
  • Low platelets
  • Anemia

Serious side effects

  • Risk of severe infection
  • Bleeding – gastrointestinal perforation and bleeding
  • Inflammation in the colon
  • Risk of cancers, lymphomas, and skin cancers
  • Risk of brain infection

Working of Mycophenolate

It downregulates the activity of B cells and T cells. Suppresses the immune system. Helps prevent rejection of the new organ when transplanted in the body. Reduces anaphylactic immune response.

Benefits

  • More selective action, target immune cells
  • Do not harm other cells
  • Reduces the need for steroids
  • Minimizes the risk of rejection
  • Maintain immune tolerance
  • Supports long-term graft survival

Precautions

To be used cautiously in:

  • Kidney impairment
  • Bleeding disorders
  • Active infection
  • Underlying cancer
  • Leukemia
  • Elderly patients

Safety instructions

  • Maintain contraception during the treatment
  • Avoid live vaccines (MMR, Varicella) due to a compromised immune system

Contraindications

  • Should not be used in pregnant women and breastfeeding mothers
  • Hypersensitivity or allergy to drug components

Warnings

To be used under medical prescription.

Drug Interactions

  • Antiviral
  • Antacids
  • Antibiotics
  • And Other immune suppressants

Important Monitoring Considerations

Monitor for –

  • Total blood count
  • Liver and kidney functions

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