Sofosbuvir + Ledipasvir

Classification: Hepatitis C Medicine

Sofosbuvir + Ledipasvir combination –

  • Trusted combination of antiviral drugs effective against Hepatitis C genotypes 1,4,5,6.
  • Can be used in cirrhosis (both compensated and decompensated).
  • Can be used in HIV co-infections.
  • In children > 3 years
  • Can be used post-liver transplant

Uses

  • Chronic Hepatitis C
  • HCV-HIV co-infections

Working of Sofosbuvir and Ledipasvir

It inhibits viral cell replication by inhibiting two different protein polymerases, offering potent viral suppression.

Benefits

  • Short-term treatment
  • High cure rates
  • Low resistance risk
  • Well tolerated
  • Reduces liver damage

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Digestive issues
  • Tiredness
  • Muscle pain
  • Joint pain

Serious Side Effects

  • Severe Bradycardia (when taken with amiodarone)
  • Causes Hepatitis B reactivation
  • Severe liver failure
  • Severe anemia upon use with ribavirin
  • Depression, mood swings, and confusion

Precautions

To be used cautiously in patients with:

  • Kidney disorders
  • Cardiac disorders
  • Liver disorder
  • Hepatitis B co-infections
  • HIV co-infection
  • When used with ribavirin and amiodarone

Contraindications

  • Allergy or hypersensitivity to drug components
  • Breastfeeding mothers
  • Pregnant women

Should not be used with Amiodarone, Antacids, and Proton pump inhibitors.

Warning

To be taken under the instructions of the doctor.

Important Safety and Monitoring Information

  • Regular monitoring of hepatic, renal, and cardiac functions
  • Co-infections
  • Neuropsychiatric adverse reactions
  • Drug interactions – Ribavirin and Amiodarone
  • Not to be used alone for HCV infections

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