Sorafenib
Classification – Anticancer Medicine
What is Sorafenib?
It is an anticancer medication used for advanced cancers of the liver and kidney that cannot be treated with surgery, or for differentiated thyroid cancer that has recurred or spread to other parts of the body.
Uses of Sorafekast
- • Hepatocellular carcinoma
- • Renal cell carcinoma
- • Thyroid carcinoma (Radioactive iodine-refractory differentiated thyroid cancer)
How does Sorafekast work?
It is a multikinase inhibitor.
It inhibits several protein kinases.
It inhibits new blood vessel formation, cuts off the blood supply and oxygen to cancer cells, causing cancer cell death.
Common Side Effects
- • High blood pressure
- • Weight loss
- • Hair loss
- • Diarrhea
- • Skin rashes
- • Mouth ulcers
- • Pain in the abdomen
- • Delayed wound healing
Serious Side Effects
- • Gastrointestinal bleeding
- • Risk of blood clotting
- • Heart complications – heart attack, stroke
- • QT prolongation – irregular heartbeats
- • Severely high blood pressure
- • Skin peeling and ulceration
- • Visual changes, headaches, and seizures
Precautions
To be used cautiously in patients having:
- • Advanced liver dysfunctions
- • Hypertensive patients
- • Cardiovascular disorders
- • Blood disorders
- • Planning surgery
- • Thyroid disorders
Contraindications
- • Not to be used if any previous allergy or hypersensitivity to Sorafenib or any excipients
- • Breastfeeding mothers
- • Pregnant women
Warnings
To be used under the supervision of a medical practitioner or oncology specialist, having adequate diagnostic and monitoring facilities.
Important Safety and Monitoring Information
Regularly monitor cardiac functions, hepatic, renal functions, skin colorations, thyroid functions, and bleeding functions.
