Sorafenib

Classification - Anticancer Medicine

Sorafenib?

Used as an anti-cancer treatment for liver /kidney cancer or relapsed thyroid cancer.

Gold standard sorafinib preparation - Sorafekast

Uses of Sorafenib -

Liver cancer

Kidney carcinoma

Thyroid carcinoma

Radioactive iodine-refractory differentiated thyroid cancer

Working of Sorafinib?

It is a multikinase inhibitor

It inhibits several protein kinases

It inhibits new blood vessel formation, cuts off the blood supply and oxygen to cancer cells, causing cancer cell death.

Common side effects

High blood pressure

Weight loss

Hair loss

Diarrhea

Skin rashes

Mouth ulcers

Pain in the abdomen

Delayed wound healing

Serious side effects

Gastrointestinal bleeding

Risk of blood clotting

Heart complications- heart attack, stroke

QT prolongation -irregular heartbeats

Severely high blood pressure

Skin peeling and ulceration

Visual changes, headaches, and seizures

Precautions

To be used cautiously in patients having

Advanced liver dysfunctions

Hypertensive patients

Cardiovascular disorders

Blood disorders

Planning surgery

Thyroid disorders

Contraindications

Not to be used in allergy or hypersensitivity to sorafenib or the drug components.

Breastfeeding mothers

Pregnant women

Warnings

To be used under the supervision of a medical practitioner or oncology specialist, having adequate diagnostic and monitoring facilities.

Important safety and monitoring information

Regularly monitor cardiac functions, hepatic, renal functions, skin colorations, thyroid functions, and bleeding functions.

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