Bortezomib

Bortezomib

• Classification\- Anticancer

What is Bortezomib?

It is a targeted anticancer medicine used widely for the treatment of blood cancer and cancer of the mantle cells.

Uses of Bortezomib

• Multiple Myeloma
• Mantle cell lymphoma

Working of Bortezomib

It causes protein buildup in the cells, stressing the cells and inhibiting cell growth.

Common side effects

• Nausea
• Vomiting
• Tiredness
• Low blood count
• Risk of infection

Serious side effects

• Bone marrow suppression
• Peripheral neuropathy
• Severe infections
• Bleeding
• Anemia
• Hypotension
• Cardiac arrhythmias or heart failure
• Respiratory distress
• Liver inflammation
• Renal dysfunctions
• Neurological conditions - confusion, headache, seizures

Precautions:

• To be used cautiously in
• Liver dysfunction
• Kidney disorders
• Elderly patients
• Heart problems
• Nerve problems

Contraindications

• Hypersensitivity or allergy to drug components.
• Pregnant and breastfeeding women

Warnings

• To be used under medical prescription.
• Herpes zoster reactivation

Important Monitoring Considerations

• Check for -
• Liver function - elevated liver enzymes
• Neurological conditions
• Cardiovascular functions
• Renal functions
• Infections
• Neuropathy assessment
• Electrolytes, uric acid

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