Daclatasvir
- Daclatasvir
- Clasification : Hepatitis C medicine
What is Daclatasvir?
It is Hepatitis C medicine used for the treatment of chronic hepatitis c.
How does it work?
- It causes conformational changes in viral cell structure.
- It inhibits viral cell replication and assembly
Uses of Daclatasvir -
- Chronic Hepatitis C
- Against HCV strains -1-3 and others
- HCV infections- it is used in combination, not to be used alone.
How does Daclatasvir work?
- NA5A protein inhibition
- It inhibits viral replication, assembly, and release
- Block new viral cell formation
Benefits -
- Rapidly reduces viral load
- Well tolerated, fewer side effects
- Shorter treatment duration
- Broad spectrum of activity (genotypes 1-3)
- Safe in HIV co-infections
- Can be used in compensated cirrhosis
- Can be used post-liver transplant
- Less risk of the development of resistance
Common Side Effects
- Nausea, dizziness, headache, digestive issues, tiredness, diarrhea
Severe Side Effects
- Severe fall in RBC count when used with Ribavirin
- Anxiety, confusion
- Elevated liver enzymes, or hepatic decompensating in advanced-stage liver disorder
- Low heart rate when used with Amiodarone
Precautions
- To be used cautiously in patients -
- Heart disorder
- Decompensated liver cirrhosis
- HIV co-infections
- Drug interactions
Contraindications
Not to be used if any previous allergy or hypersensitivity to Daclatasvir, or any excipients.
- Breastfeeding mothers
- Pregnant women
Warning
To be taken when prescribed under the supervision of a specialist.
Important Safety and Monitoring Information
Regular monitoring of hepatic functions, renal functions, cardiac functions, co-infections,
- Drug interactions - Ribavarin and Amiodarone
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Top-selling Hepatitis C medicine - Dacikast
Formulations based on "Daclatasvir" (9)
Qurdac
Daclatasvir
It is a daclatasvir tablet. It is manufactured by Strides Pharma.
Hepcinat Plus
Sofosbuvir / Daclatasvir
It is daclatasvir and sofosbuvir tablet. It is manufactured by Natco Pharma.
Sofokast Plus
Sofosbuvir / Daclatasvir
Sofokast Plus is a combination of 2 direct acting antivirals, effectively used against Hepatitis C virus.
Dacikast
Daclatasvir
It is a hepatitis C medicine, often used in combination with other drugs for HCV infections.
MyHep DVIR
Sofosbuvir / Daclatasvir
MyHep DVIR (Sofosbuvir / Daclatasvir) is an authenticated pharmaceutical product supplied under WHO-GMP compliance globally from Gandhi Medicos.
Hepcdac
Daclatasvir
Hepcdac 60 mg (Daclatasvir) is an anti-viral agent indicated for patients with different variants of hepatitis C viral (HCV) infection. Hepatitis C is caused by a single-stranded (ss) RNA virus whi...
DaciHep 60 mg (Daclatasvir)
Daclatasvir
Hepatitis C viral (HCV) infection is a liver disease caused by single-stranded (ss) RNA viruses categorized into 9 distinct genotypes. DaciHep 60 mg (Daclatasvir) with its potent inhibitory action ...
Daclahep
Daclatasvir
Daclahep 60 mg (Daclatasvir) is an anti-viral agent indicated for patients with different variants of hepatitis C viral (HCV) infection. Hepatitis C is caused by a single-stranded (ss) RNA virus wh...
Mydekla 60
Daclatasvir
MyDekla 60 mg (Daclatasvir Dihydrochloride) is a direct-acting antiviral (DAA) inhibitor drug specified for patients with chronic Hepatitis C viral (HCV) infection with genotype 1 or 3. After enter...