Bleomycin

• Bleomycin
• Classification - Anticancer medicine

What is Bleomycin?

It is an anticancer medicine derived from a bacterium and is widely used for solid tumors and various cancers of the head and neck.

Uses of Bleomycin

• Squamous tissue Carcinomas - head, neck, penis, uvula
• Hodgkin's lymphoma
• Non-Hodgkin's lymphoma
• Pleural Effusion,Malignant
• Testicular Carcinoma

How does it work?

• It breaks the DNA strands, inhibiting their replication or multiplication

Common side effects

• fever and chills
• Mouth ulcers
• Skin rashes
• GIT upset
• Hair loss
• Tiredness
• Reduced appetite

Serious side effects

• Bone marrow suppression
• Liver toxicity
• Severe skin peeling, ulceration
• Scarring of lung tissue
• Pulmonary toxicity -shortness of breath,
• Allergic reaction - difficulty breathing, skin flare

Precautions:

• To be cautiously used in -
• Pre-existing respiratory disorders
• Smoking
• Elderly patients
• Heart problems
• Kidney impairment
• Undergoing surgery
• Concurrent radiation therapy

Contraindications

• Not to be used in patients-
• Hypersensitivity to bleomycin
• Pregnant and breastfeeding women

Warnings

• Prescription drug to be used under medical supervision.

Important safety and monitoring information

• Respiratory functions
• Liver functions
• Kidney functions
• Blood count
• Local necrosis

Storage

• Store at 2-8 degrees Celsius,
• Protected from light.

Administration Instructions

To be administered as a slow IV infusion over 15-60 minutes.

• Globally prescribed bleomycin formulation - Bleokey

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