Ketoconazole

Ketoconazole 200 Mg

• Classification -Antifungal Medicine

Ketoconazole- 200 mg?

It is used for various systemic fungal infections and yeast infections.

Uses -

• Systemic fungal infections
• Mucocutaneous candidiasis
• Tinea infections
• Dermatitis
• Deep-seated fungal infections
• Psoriasis, caused by a fungal infection

Working of Ketoconazole -

• Breaks the fungal cell membrane integrity.
• Causes fungal cell death.

Common Side Effects -

• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Stomach ache

Severe Side Effects -

• Painful skin rashes
• Menstrual irregularities
• Gynecomastia
• Sexual dysfunction
• Arrhythmia
• Suppression of the adrenal glands
• Liver dysfunction
• Jaundice
• Electrolyte imbalance

Toxicities:

• Liver toxicity
• Adrenal insufficiency
• Arrhythmia
• QT prolongation

Precautions:

• To be used cautiously in patients with
• Any heart problem
• Liver disorders
• Alcohol abuse
• Achlorhydra

Contraindications

• Not to be used in patients -
• Hypersensitive or allergic to the drug composition.
• Breastfeeding mothers
• Pregnant women

Warning

• To be used under medical prescription only

Important Safety and Monitoring Information

• Regularly monitor-
• Liver function
• Heart rhythms and
• Hormonal functions

Drug interactions

• Ketoconazole should be used with extreme caution with
• Cholesterol medicines- statins, fibrates
• Anticoagulants- Warfarin, Heparins
• Cardiovascular drugs-beta blockers ,calcium channel blocker
• Antihypertensive- diuretics , ACE ace inhibitors
• Immunosuppressant- corticosteroids
• HIV- DDA
• Antipsychotics- antidepressants

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