Veenat 100 mg Drug Overview

Veenat 100 mg is one of the newest drugs in the pharmacological family of antineoplastic agents. It has cytotoxic properties. These properties are classified according to the influence of the drug on the specific mutated enzyme BCR ABL tyrosine kinase. This enzyme is responsible for the growth of tumors in chronic myelogenous leukemia.

This article contains information about the drug, but, in no way whatsoever, promotes self-medication. This drug should be used only on the advice of a doctor and according to his prescription.

The drug may have severe side effects, and taking them without consulting a doctor is strictly not advisable.

Instructions for use-

The following are the main characteristics of the Veenat 100 mg drug:

The name for commercial use and distribution is Veenat 100 mg Imatinib.

The primary substance in the drug is Imatinib or Imatinib mesylate. It was discovered after a lot of research by reputed scientists in the last decade of the 20th century.

The drug comes in the form of capsules, with each package having 120 capsules. Natco Pharma Ltd. (India) manufactures this drug.

The drug may help in the treatment of all forms of chronic myelogenous leukemia. They may help in all stages that is the chronic phase, or during exacerbation of the disease or the stage of blast crisis. The drug may help in the absence of treatment or inoperable conditions of malignant gastrointestinal tumors.

The drug gives very high (almost 100%) success in curing the disease and offers excellent results in monotherapy.

The Veenat 100 mg Imatinib can be bought online or directly from the company by contacting the representatives.

The price of one package of this drug from the company is about 200-300 USD or 14200-16200 INR.

Composition and Components of the drug-

The drug contains one primary active ingredient and several secondary or auxiliary substances

• Imatinib mesylate is the primary active ingredient
• Microcrystalline cellulose acts as the filler for the medicine.
• Lactose from milk sugar is used to dilute the drug
• Anhydrous colloidal silicone increases the substance’s flowability during the initial stages of production and thus improves accuracy in production
• Magnesium stearate is used to bind and mix all the ingredients properly to form a homogeneous mix.
• Crospovidone enables the capsule and its ingredients to be dissolved quickly and easily in the gastrointestinal tract.
• Purified talcum powder provides silicon and magnesium in medicine.

All of these components in the correct mix give superior qualities to this medicine, like a good rate of dissolution, easy bio-availability (close to 98%) of the nutrients, and long-term shelf life.

Working of the drug-

Chronic myeloid leukemia (CML) is a generally rare disease. In this disease, malignant tumors develop in the hematopoietic system. The disease develops very slowly in comparison to acute leukemia, so it is termed as chronic. Usually, the elderly are most at risk of this disease. Children are generally not affected. However, cases have been seen in all ages.

The disease undergoes development in a somewhat interesting manner. In this disease, two chromosomes of the cells get mutated, chromosome number 9 and 22. Parts of both the chromosomes are interchanged. This interchanging is the primary cause of the development of CML. This abnormal gene is called “Philadelphia” or abnormal BCR ABL gene. This whole process is called translocation.

A normal protein is responsible for the generation of a correctly-functioning enzyme tyrosine kinase; however, this mutated gene condition leads to the production of a mutated, wrongly functioning enzyme. This enzyme is responsible for the conversion of healthy cells into malignant ones. This leads to the stopping of aging and dying of leukemia cells, and their release into the blood from the bone marrow increases.

This is where the Veenat 100 mg Imanitib drug works its magic. Its active ingredient blocks the mutated enzyme tyrosine kinase formed due to the mutated chromosome.

This drug stops the proliferation of malignant tissues and leads to the death of cells with the mutated gene and also the leukemia cells.

 Contraindications-

Contraindications are the possible reasons why the medication of this drug should be stopped. They also include the precautions that should be taken before the regular usage of this drug.

Sometimes these drugs cannot have a variety of severe side effects. Thus, there can be times when there are reasons to stop this medication.

There can be cases of hypersensitivity to the main active ingredient. Since the drug also contains amounts of lactose, it can be a problem for people with lactose intolerance.

Proper tests and studies have also not been conducted for children, especially below the age of 3. So, it is not particularly recommended for children of that age group.

The drug is also not recommended for pregnant mothers. The benefits of medicine over its possible side effects have to be calculated. Lab tests with pregnant rats led to stillbirths and nonviable offspring. So, it is not particularly considered to be safe for expectant mothers.

The drug contains Imanitib that can penetrate breast milk. So, breastfeeding should be kept at a minimum while the treatment of breastfeeding women.

Side effects-

The drug has a variety of side effects, which, unless due to individual intolerance, are usually dose-oriented.

In general, the side effects of the drug, according to the organ system can be:

Musculoskeletal: bone and muscle pain, muscle spasms, myalgia.

 Gastrointestinal tract: nausea, vomiting, diarrhea, bleeding, dyspepsia, constipation, and abdominal pain.

 Nervous system: dizziness, insomnia, fainting, drowsiness, memory impairment, migraine, depression, headache, and hemorrhage.

 Skin: Skin rashes and itching.

Water balance: pulmonary edema, subcutaneous tissue swelling, pericardial effusion, ascites, the appearance of pleural effusion, and retention of fluids in the body.

 Respiratory system: nasopharyngitis, pneumonia, coughing, dyspnea, sinusitis, pharyngitis, and other infectious diseases.

Metabolism: anorexia, appetite disorder, gout, increased uric acid levels, weight gain, hypokalemia, and hyperkalemia.

 Hepatology: Sometimes, there can be an increase in the amounts of transaminases and bilirubin.

Hematology: neutropenia, oppression of bone marrow, hematopoiesis, thrombocytopenia, anemia. Also, hematological toxicity was developed and observed in all cases by cytopenia.

 Visual organs: eye irritation, macular edema, papillary edema, glaucoma, hemorrhages, conjunctivitis, and increase of lachrymation.

Cardiovascular system: tachycardia, hot flashes, pericarditis, cold extremities, arterial hypertension, and heart failure.

Reproductive system: swelling of the scrotum, breast enlargement, decreased potency, pain in the nipples, and gynecomastia.

 Urinary system: frequent urination, renal pain, and kidney pain.

Other than these, some other general side effects such as anxiety, flu, chills, fever, and other diseases are not so common or evident in the subjects studied and under consideration. How much of the side effects are severe, and the frequency of the side effects’ appearance depends on the stage that the disease is in. They also depend on the quantity or dosage of the drug that is being used.