Hepakast Sachet
It is the combination of three branched-chain amino acids (BCAAs) including L-leucine (2760 mg), L-isoleucine (1920 mg) and L-valine (1656 mg) combined in a sachet. Hepakast (L-leucine, L-isoleucine and L-valine) is indicated in patients suffering from different types of liver diseases including,
- Liver cirrhosis (scarring of the liver)
- Hepatic encephalopathy (Loss of brain functions which occurs due to liver damage)
- Hepatitis B and C
- Steatohepatosis (Liver inflammation caused by gathering concurrent fat in the liver)
- Post liver transplant surgery
Hepakast (L-leucine, L-isoleucine and L-valine) compensates the protein deficiency by supplementing these BCCAs (proteins are made of amino acids), as patients with cirrhosis or liver failure cannot absorb BCAAs completely from the food. It is specifically utilized in patients who cannot undertake standard therapeutic options. The absence of BCAAs renders a weakened immune system, deteriorates the mental state of the patients and leads to cognitive impairment.
Functions of Hepakast (L-leucine, L-isoleucine and L-valine):
- Restoring the functions of the liver
- Preventing hepatic failure
- Refining muscle mass, overall weakness and tiredness (Fatigue)
- Improving clinical outcomes in patients with advanced cirrhosis
- Rejuvenating quality of life and survival of patients
Hepakast (L-leucine, L-isoleucine and L-valine) is taken with luke-warm water (200 ml) twice (2 sachets) per day. It is devoured 30 to 40 minutes before the meal. In terms of mechanism, the drug shows its ability to participate in energy and metabolic processes in the body. It acts in several directions like,
- Inhibiting the death of liver cells (Regeneration of parenchyma)
- Producing albumin and glycogen (Types of sugar used in metabolic processes)
- Reducing the growth of cancerous liver cells
- Maturing the nerve cells processes
- Speeds-up the synthesis of lymphocytes
- Decreasing liver cell replacement with fibrous tissue
Side-effects associated with Hepakast (L-leucine, L-isoleucine and L-valine):
Most common side-effects:
- Loss of co-ordination
- Tiredness (Fatigue)
- Nausea
- Vomiting
- Diarrhea
- Bloating
Rare side-effects:
- High blood pressure (Hypertension)
- Headache
- Whitening of skin
Note: Hepakast (L-leucine, L-isoleucine and L-valine) might show other side-effects as well. If you need more information please consult your doctor.
When should Hepakast (L-leucine, L-isoleucine and L-valine) be avoided or used cautiously?
- If patients are suffering from inflammation and severe liver failure
- If patients have kidney diseases
- If patients are pregnant or breastfeeding or planning to get pregnant or breastfeed
- If children are below 6 months of age, avoid Hepakast (L-leucine, L-isoleucine and L-valine
FAQs for Hepakast Sachets
The active ingredients of a Hepakast sachet are three branched-chain amino acids (BCAAs)- L-valine, L-leucine, and L-isoleucine in a sachet.
A Hepakast sachet is recommended for liver diseases, including liver cirrhosis, Hepatitis B and C, Hepatic Encephalopathy, Steatohepatitis, and post-liver transplant surgery.
Hepakast contains BCAAs that compensate for the protein deficiency as patients with liver conditions like cirrhosis or liver failure will not be able to draw the BCAAs from their food. Therefore, patients who cannot undergo standard therapeutic options resort to Hepakast.
L-leucine constitutes 2760 mg, L-isoleucine constitutes 1920 mg, and L-valine comprises 1656 mg in a Hepakast sachet.
The shelf life of Hepakast is two years.
Aprazer Healthcare manufactures Hepakast sachets.
Intake of Hepakast restores the proper functioning of the liver, prevents hepatic failure, improves the clinical outcomes of patients in advanced stages of cirrhosis, refines the muscular mass, and reduces the overall fatigue. It also rejuvenates the survival and quality of life of the patients.
Two Hepakast sachets have to be administered with lukewarm water of about 200ml twice a day. The drug has to be administered 30 to 40 minutes before eating.
Hepakast should be administered before meals as they participate in metabolic processes, reduce liver cells’ death, cut down the growth of cancerous liver cells, and are involved in liver cell replacement with fibrous tissues. They also help in the maturation of nerve cell processes and the production of glycogen and albumin.
Common side-effects of Hepakast include nausea, vomiting, bloating, diarrhea, loss of coordination, and fatigue. Patients could, in rare circumstances, experience skin whitening, high blood pressure, and headache. There are other side-effects of Hepakast about which a doctor can explain better. The sachet should not be crushed, chewed, or broken.
Patients with liver diseases and inflammation, kidney diseases, are planning to or are pregnant or breastfeeding. In addition, patients with a history of chronic alcoholism have to check with their doctor whether they could intake Hepakast. There is a possibility that the BCAAs in Hepakast can cause liver disease that leads to hepatic encephalopathy.
No, Hepakast should not be administered for children below six months. This is because the intake of leucine, one of the BCAAs that make up Hepakast, can cause insulin release from the pancreas, lowering blood sugar levels.
The BCAAs in Hepakast have the approvals of the European and American Associations for the Study of Liver Disease and by the European Association for Clinical Nutrition and Metabolism.
Hepakast should not be consumed with grapy juice. Consuming the drug with grapy juices can increase the severity of the side- effects. In addition, Hepakast should not be consumed for two weeks before surgery as it could impact the patient’s blood sugar levels. Cautious use is recommended while doing activities that involve motor coordination, like driving.
Hepakast is a prescription drug and has to be administered only with a doctor’s advice and prescription.
Hepakast is primarily used for liver disease. However, research is being conducted about the efficacy of the BCAAs found in Hepakast on other conditions like renal failure, burn injury, cancer, trauma, and sepsis. Unfortunately, the positive effects of BCAAs, and thereby Hepakast, in treating other diseases is not conclusively proven. Therefore, it is safe not to try the drug for other conditions.
BCAAs could give way to diabetes if consumed in excess. However, it is not confirmed whether Hepakast as a drug can give way to these conditions. Therefore, Hepakast should only be consumed according to the prescription of the doctors.
BCAAs, also found in Hepakast, are shown to interfere in renal function and cause kidney fibrosis. However, Hepakast as a drug is not confirmed to cause kidney disease. Therefore, it is better to seek a doctor’s opinion about the drug.
No, prescribed consumption of Hepakast is not ascertained to cause weight gain, though the BCAAs are known to increase muscle mass. Therefore, a doctor’s opinion has to be sought in this regard.
Both Hepamerz and Hepakast are drugs for treating liver disease. However, Hepamerz is sold as tablets while Hepakast is sold as sachets.
Yes, Hepakast and Hepamerz have to be used with caution by pregnant or breastfeeding women, alcoholics, and people with kidney diseases.
Though it is true that both drugs are used to treat the same disease and exhibit similar symptoms, and require similar sets of precautions on similar groups of people, Hepamerz cannot and should not be substituted for Hepakast without a doctor’s advice.
Hepakast sachets have to be stored at a temperature between 10 to 30° C. The sachet should not be exposed to heat or light lest the humidity damages the quality of the drug.
Hepakast sachets are packed in batches of 10 sachets with a dosage strength of 10mg.
Purchase of Hepakast sachets takes place without intermediaries. The suppliers ensure that they comply with the medical regulations concerning packing, packaging, and moving. The packaging is done to survive international travel and not let humidity affect the drugs.
Angela –
Hepakast – the best medicine I can recommend for anyone who got jaundice.
Jordan Jones –
Hepakast was recommended by my family doctor. My health has improved since I started taking it.
Ryan Smith –
It is the most effective treatment for liver disease. I’m stating this after three months of use.