Mitomycin

Mitomycin

Composition: Mitomycin 10mg

Therapeutic class: It is an Anti-neoplastic, an antibiotic

What is Mitomycin?

Mitomycin is used as an anticancer medicine against many cancers and solid tumors.

Uses of Mitomycin

• Stomach cancer
• Pancreatic cancer
• Ovarian cancer
• Breast cancer
• Uterus cancer
• Small cell lung cancer

How does Mitomycin work?

It gets attached to DNA, forms cross-links in the DNA, inhibits replication, and division, causing cancer cell death.

Common Side Effects

• Nausea
• Bone marrow suppression
• Mouth ulcers
• Alopecia
• Skin rashes

Serious Side Effects

High doses can lead to:

• Anemia
• Low platelet count
• Lung scarring
• Kidney damage
• Liver toxicity
• Shortness of breath
• Fast irregular heartbeat

Precautions

To be cautiously used in:

• Pre-existing liver disorder
• Kidney disorder
• Bleeding disorders
• Severe infection
• Elderly patients
• Mylosuppressant therapy
• Respiratory infection
• Asthma
• Anemic

Contraindications

• Not to be used if any previous allergy or hypersensitivity to Mitomycin or any excipients.
• Breastfeeding mothers
• Pregnant women

Warning:

To be used under the supervision of a medical practitioner or oncology specialist, having adequate diagnostic and monitoring facilities.

Important safety and monitoring information

Monitor-

• Total blood count
• Renal functions
• Pulmonary functions
• Hepatic functions
• Local tissue necrosis

Storage

It should be stored at 2-8 degrees Celsius, protected from light.

Administration Instructions

• To be administered as a slow IV infusion.
• Avoid IV push or rapid bolus.
• To be used immediately after reconstitution.