Qurled

Qurled 400 mg (Sofosbuvir) is an anti-viral drug indicated against chronic hepatitis C (HCV) infection with genotype 1-4. Sofosbuvir is known for its direct-acting antiviral (DAA) properties inhibiting non-structural protein 5B (NS5B) protein, a special type of protein responsible for multiplication (RNA replication and virion assembly) of viral cells.

For achieving a sustained virologic response (SVR), sofosbuvir is used with other anti-HCV agents assisting in,

• Reduction of damages associated with liver
• Improvement in the quality of life of patients
• Liver cancer incidence

Administration of Qurled 400 mg (Sofosbuvir):

Qurled 400 mg (Sofosbuvir) is administered orally once in a form of 400 mg dose taken with or without food. In addition, either ribavirin alone or ribavirin plus pegylated interferon is also recommended.

Table: Dosage regimen for Qurled 400 mg (Sofosbuvir)

Note: Both pros and cons should be taken into consideration before increasing the duration of treatment.

Once swallowed, sofosbuvir is absorbed (bio-available) in between 30 mins to 2 hours with a binding affinity of 61-65% with viral cells. It is generally metabolized in the liver and after its activities, more than 50% of the drug is excreted from the body in between 40 minutes to 27 hours.

When should Hepcinat 400 (Sofosbuvir) be avoided or used cautiously?

Interactions with other drugs:

If patients were taking other drugs before or along with sofosbuvir,

• The efficacy gets comprised
• Dosages need to be modified
• Shows a higher rate of side-effects

Other warning signs:

If patients are suffering from or had,

• History of Hepatitis B viral infection before taking sofosbuvir.
• Liver transplant before the initiation of dosage
• Complications in the liver other than HCV infection
• Heart problems
• Kidney disease or undergoing dialysis
• HIV infection
• Other severe medical condition

Issues during child-birth if patients,

• Are pregnant or planning to get pregnant
• Are male and your partner is planning to get pregnant
• Are breastfeeding or planning to breastfeed

Side-effects of Qurled 400 mg (Sofosbuvir):

Sofosbuvir has a reasonable safety profile with minimal side-effects. Due to its safety profile, it has a therapeutic advantage over other anti-HCV agents like the absence of low red blood cell (RBC) count (anemia) and neuropsychiatric effects.

Serious side-effects: Slow heart rate (bradycardia)

Side-effects in combination with ribavirin:

• Headache
• Tiredness (Fatigue)

Side-effects in combination with ribavirin and pegylated interferon:

• Lack of sleep (Insomnia)
• Nausea
• Tiredness (Fatigue)
• Headache

Uncommon side-effects: 

• Pain in the muscles (Myalgia)
• Physical weakness (Asthenia)
• Skin itchiness (Pruritis)
• Diarrhea
• Severe rashes on the skin
• Fever
• Chills
• Low consumption of diet

Note: These are not all possible side-effects of Qurdac 400 mg (Sofosbuvir), please ask your doctor for more information regarding the same.