Ribasure 200 mg (Ribavirin)

Patients with a compensated liver disease face a lot of problems when they are diagnosed with Hepatitis C viral (HCV) infection. In this regard, Ribasure 200 mg (Ribavirin) is a potent option due to its sustainable anti-HCV properties. Ribasure (Ribavirin) is also recommended in HCV patients with HIV-1 co-infection.

For overall care of the patients, Ribasure 200 mg is recommended along with peginterferon alfa. Their combination has shown to achieve a 70% response against HCV patients with genotype 2, 3 and 4 whereas 44% in genotype 1 patients. Ribavirin acts by hindering the process of multiplication (RNA/DNA replication) in HCV cells. However, the exact mechanism of action is not fully understood yet.

Ribasure 200mg (Ribavirin) is taken in the form of oral dosage. It is to be taken with food two times a day – in morning and in evening. The medicine is to be taken for about six months to a year. It is advised to take Ribasure 200 mg (Ribavirin) around the same time each day. One should follow the directions on prescription label carefully and seek doctor’s or pharmacist’s advice to understand any aspect of taking this medicine, that is not clear.

Ribasure 200mg (Ribavirin) is used along with other antiviral medicines such as interferon, sofosbuvir for treatment of chronic Hepatitis-C (liver viral infection). Hepatitis-C infection can cause serious liver problems like scarring (cirrhosis) or even liver cancer.

Administration of Ribasure 200 mg in chronic HCV adult patients:

HCV disease type	Bodyweight	Dosage regimen (daily)	Number of tablets	Duration (weeks)
Genotype 1,4	<75 kgs	1000 mg	2 × 200 mg tablets (morning) 3 × 200 mg tablets (evening)	48
	≥75 kgs	1200 mg	3 × 200 mg tablets (morning) 3 × 200 mg tablets (evening)
Genotype 2,3	–	800 mg	2 × 200 mg tablets (morning) 2 × 200 mg tablets (evening)	24
With HIV coinfection (All genotypes)	–	800 mg		48

Ribasure 200mg (Ribavirin) precautions and warning signs:

Liver impairment warnings:

Administration of ribasure 200 mg may cause concerns in the liver. These concerns include,

• A type of hepatitis caused by our immune system damaging the liver (autoimmune hepatitis)
• Occurrence of a severe liver disease
• Hepatitis B viral infection

Other organ defects:

• Mental health problems like depression or anxiety
• Kidney complications
• Thyroid disease
• History of cancer or diabetes
• High blood pressure (hypertension)
• Heart attack
• Disorders related to blood especially low count of red blood cells (anemia)

Other scenarios where Ribasure should be avoided:

If patients,

• Had an experience with interferon-based therapy for HCV infection but did not work
• Had or planning to have an organ transplant (liver)
• Are allergic to any ingredients in the ribavirin
• Are pregnant or planning to get pregnant
• Are male and the partner is planning to get pregnant
• Are breastfeeding or planning to breastfeed

Side-effects of Ribasure (Ribavirin)

Serious side-effects:

• Harm to the unborn child
• Low count of red blood cells (Anemia)
• Problems in the liver with the symptoms like stomach bloating, brown urine and yellow eyes

Most common side-effects:

• Tiredness (Fatigue)
• Nausea
• Rashes and itching on the skin
• Cough
• Loss of appetite

Uncommon side-effects:

• Shortness of breath (Dyspnea)
• Swelling
• Chest pain
• Severe pain in the stomach and lower back
• Diarrhea with blood (bowel movements) looking like black tar
• Unusual bleeding (Hemorrhage)
• Vision problems
• High fever (>100.5-degree F)
• High depression

Note: These are not all possible side-effects of Ribasure, please ask your doctor for more information regarding the same.

Ribasure 200 mg is also available in these countries: (South East Asia, South America, Eastern Europe, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Macedonia, Poland, Republic of Kosovo, Republic of Moldova, Romania, Russia, Serbia, Slovak Republic and Slovenia.)