Sofokast plus

Composition- Daclatasvir and Sofosbuvir

Classification - Hepatitis C medicine

What is Sofokast Plus?

Sofokast Plus is a combination of 2 direct acting antivirals, effectively used against Hepatitis C virus.

Uses of Sofokast Plus

Chronic Hepatitis C

HIV co-infections

How does Sofokast Plus work?

Sofosbuvir -NS5B polymerase inhibitor, it stops the viral DNA from producing its copies.

Daclatasvir - NS5A protein inhibitor, stops viral multiplication and assembly.

Benefits -

Significantly reduces viral load within 12 weeks.

Has a broad spectrum of activity against all genotypes.

It can be used after a liver transplant to prevent recurrence.

Can be used in HIV co-infections

Can be used in cirrhosis (compensated /decompensated)

Common Side Effects

Nausea,

Dizziness,

Headache,

Digestive issues,

Tiredness,

Diarrhea

Serious side effects

Severe Bradycardia (when taken with amiodarone)

Hepatitis B flare-ups in co-infections.

Liver failure in advanced liver disease.

RBC count drops severely when used with ribavirin.

Precautions

To be used cautiously in patients

Kidney disorders

Liver disorder

Hepatitis B co-infections

When used in combination with ribavirin and amiodarone

Contraindications

Allergy or hypersensitivity to drug components.

Breastfeeding mothers

Pregnant women

Warning

To be used when prescribed by a doctor.

Not to be used as monotherapy for HCV infections.

Important Safety and Monitoring Information

Regular monitoring of hepatic functions, renal functions, cardiac functions, co-infections,

Sofokast Plus