Zoldokast -

Composition: Zolderonic acid IP- 4mg

Therapeutic class: Bisphosphonates

What is Zoldokast?

Cancer treatment often causes bone loss, it is widely used to treat cancer-related bone complications and osteoporosis.

Uses of Zoldokast

Osteoporosis

High calcium levels caused by malignancies

Secondary cancers in the bone

Chronic bone disorder

Bone marrow cancers

Bone lesions

How does Zoldokast work?

Osteoclast causes bone dissolution.

Inhibiting osteoclasts stops bone dissolution, preventing bone integrity.

Common side effects

Diarrhea

Loss of appetite

Bone, muscle pain

Nausea

Vomiting

Fluid retention

Dizziness

Dryness of the skin

Serious side effects

Lowered calcium levels - tingling in fingers

Kidney failure

Irregular heartbeat

Bone fractures

Osteonecrosis of the jawbone

Eye inflammation

Blood in urine

Dizziness, confusion

Shortness of breath

Rapid weight gain

Decreased vision

Precautions:

To be used cautiously in

Kidney disorders

Any dental procedures

Respiratory disorder

Elderly

Thyroid disorder

Cardiovascular disease

Vitamin D levels or low calcium levels

Contraindications

Not to be used if any previous allergy or hypersensitivity to Zolderonic acid or any excipients.

Breastfeeding mothers

Pregnant women

Warnings

To be used under the supervision of a medical practitioner or oncology specialist, having adequate diagnostic and monitoring facilities.

Important safety and monitoring information

Regular monitor -

Kidney functions

Liver functions

Cardiac functions

Renal functions

Respiratory functions

Administration Instructions

To be administered as a slow IV infusion only.

Do not give as an IV push/bolus.

To be used immediately after reconstitution.

Ensure patient hydration before infusion.

Do not mix with calcium-containing IV solutions.

Storage

It should be stored at 2-8 degrees Celsius, protected from light.

Zoldokast