Zoldokast

Zoldokast –

Composition: Zolderonic acid IP- 4mg

Classification: Bisphosphonates

What is Zoldokast?

Cancer treatment often causes bone loss, it is widely used to treat cancer-related bone complications and osteoporosis.

Uses of Zoldokast

• Osteoporosis
• High calcium levels caused by malignancies
• Secondary cancers in the bone
• Chronic bone disorder
• Bone marrow cancers
• Bone lesions

How does Zoldokast work?

• Osteoclast causes bone dissolution.
• Inhibiting osteoclasts stops bone dissolution, preventing bone integrity.

Common Side Effects

• Diarrhea
• Loss of appetite
• Bone, muscle pain
• Nausea
• Vomiting
• Fluid retention
• Dizziness
• Dryness of the skin

Serious side effects

• Lowered calcium levels – tingling in fingers
• Kidney failure
• Irregular heartbeat
• Bone fractures
• Osteonecrosis of the jawbone
• Eye inflammation
• Blood in urine
• Dizziness, confusion
• Shortness of breath
• Rapid weight gain
• Decreased vision

Precautions:

To be used cautiously in

• Kidney disorders
• Any dental procedures
• Respiratory disorder
• Elderly
• Thyroid disorder
• Cardiovascular disease
• Vitamin D levels or low calcium levels

Contraindications

• Not to be used if any previous allergy or hypersensitivity to Zolderonic acid or any excipients.
• Breastfeeding mothers
• Pregnant women

Warnings

To be used under the supervision of a medical practitioner or oncology specialist, having adequate diagnostic and monitoring facilities.

Important safety and monitoring information

Regular monitor –

• Kidney functions
• Liver functions
• Cardiac functions
• Renal functions
• Respiratory functions

Administration Instructions

• To be administered as a slow IV infusion only.
• Do not give as an IV push/bolus.
• To be used immediately after reconstitution.
• Ensure patient hydration before infusion.
• Do not mix with calcium-containing IV solutions.

Storage

It should be stored at 2-8 degrees Celsius, protected from light.