Abacavir + Lamivudine

Classification: HIV medicine

What is Abacavir + Lamivudine?

It is a fixed-dose combination used for HIV – 1 treatment. Used as an adjuvant to other antiretrovirals.

Uses of Abacavir, Lamivudine Combination

  • • To treat HIV -1 infections

How does it work?

  • • The drug combination works by inhibiting viral replication and multiplication.
  • • Terminates DNA chain elongation
  • • Causes cell death

Benefits

  • • Significantly lowers viral load
  • • Improves immunity
  • • Inhibit transmission
  • • Delays disease progression

Common Side Effects

  • • Nausea
  • • GIT upset
  • • Reduced appetite
  • • Insomnia
  • • Diarrhea
  • • Skin rashes

Serious Side Effects

  • • Fatty liver – enlarged liver size
  • • Liver toxicity
  • • Lactic acidosis
  • • Pancreatitis
  • • Allergic reaction

Precautions of Abacavir + Lamivudine

To be cautiously used in people –

  • • Liver disorders
  • • Co-infections
  • • Kidney impairment
  • • Cardiovascular disorder
  • • Alcohol use due to liver toxicity
  • • Pregnant and breastfeeding women

Contraindications

  • • Severe liver dysfunction
  • • Hypersensitivity or allergy to drug components

Warnings

To be used under medical prescription.

Hepatitis B co-infections may cause serious viral flare-ups; do not stop medication immediately.

Important Monitoring Considerations

Check for –

  • • Lactic acidosis
  • • Liver function – elevated liver enzymes
  • • Viral loads (HIV, HBV)
  • • Pancreatitis

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