Abacavir + Dolutegravir + Lamivudine

Abacavir, Dolutegravir, Lamivudine

Classification: HIV medicine

Abacavir, Dolutegravir, and Lamivudine combination?

The combination of the drugs in a fixed proportion is used for HIV -1 treatment.

Used in children and young adults.

Abacavir, Dolutegravir, and Lamivudine uses-

First-line treatment for HIV infection

Preventive or maintenance therapy of HIV

How does the combination work?

It stops viral cell multiplication and replication.

Reduces the amount in the blood

Abacavir, Dolutegravir, and Lamivudine combination is widely used. Why?

Potent viral suppression to undetectable levels

Convenient daily dosing

Lowered drug resistance

Better tolerance and adherence

Easy convenient use

Improves the immune system

Abacavir, Dolutegravir, and Lamivudine combination side-effects-

Headache

Skin rashes

Insomnia

Muscle pain

Joint pain

GIT upset

Fever

Anxiety, mood changes

Serious side effects

Overactive immune system

Hepatitis B flare

Severe allergy

Skin peeling

Liver toxicity

Severe anxiety, suicidal thoughts, and insomnia

Abacavir, Dolutegravir, and Lamivudine combination precautions-

To be used cautiously in-

Elderly persons

Co-infection-hepatitis B

Renal impairment

Liver dysfunction

Cardiovascular disorders

Neurological disorders

Pregnant and breastfeeding women

Abacavir, Dolutegravir, and Lamivudine combination warnings -

Do not use it in -

Severe liver dysfunction.

Hypersensitivity or allergy to drug components.

To be used under medical prescription.

Hepatitis B co-infections may cause serious viral flare-ups on stopping medicine abruptly.

Important functions to be monitored -

Check for -

Lactic acidosis

Liver function - elevated liver enzymes

Viral loads (HIV, HBV)

Neurological conditions

CD4 cell count

Cardiovascular functions

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