Abacavir + Lamivudine

Abacavir + Lamivudine

Classification: HIV medicine

What is Abacavir + Lamivudine?

It is a fixed-dose combination used for HIV – 1 treatment. Used as an adjuvant to other antiretrovirals.

Uses of Abacavir, Lamivudine Combination

• To treat HIV -1 infections

How does it work?

• The drug combination works by inhibiting viral replication and multiplication.
• Terminates DNA chain elongation
• Causes cell death

Benefits

• Significantly lowers viral load
• Improves immunity
• Inhibit transmission
• Delays disease progression

Common Side Effects

• Nausea
• GIT upset
• Reduced appetite
• Insomnia
• Diarrhea
• Skin rashes

Serious Side Effects

• Fatty liver – enlarged liver size
• Liver toxicity
• Lactic acidosis
• Pancreatitis
• Allergic reaction

Precautions of Abacavir + Lamivudine

To be cautiously used in people –

• Liver disorders
• Co-infections
• Kidney impairment
• Cardiovascular disorder
• Alcohol use due to liver toxicity
• Pregnant and breastfeeding women

Contraindications

• Severe liver dysfunction
• Hypersensitivity or allergy to drug components

Warnings

To be used under medical prescription.

Hepatitis B co-infections may cause serious viral flare-ups; do not stop medication immediately.

Important Monitoring Considerations

Check for –

• Lactic acidosis
• Liver function – elevated liver enzymes
• Viral loads (HIV, HBV)
• Pancreatitis

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