Afatinib Dimaleate

Classification: Anticancer Medicine

What is Afatinib Dimaleate?

It is an anticancer medicine used for lung cancer.

Uses

  • • No small lung cancer
  • • Advanced NSCLC
  • • Recurrent lung cancer
  • • Mutations of the EGFR genes

How Does it Work?

  • • It blocks EGFR activity.
  • • It stops its growth and multiplication of cancer cells
  • • Causes the starvation of cancer cells

Benefits of Using Afatinib Dimaleate

  • • Strong irreversible binding
  • • Broad spectrum of activity
  • • Slows disease progression
  • • Used in failed chemotherapy
  • • Better tolerated than chemotherapy

Common Side Effects

  • • Diarrhea
  • • Skin and nail changes
  • • Mouth ulcers
  • • Nausea
  • • GIT upset
  • • Reduced appetite

Serious Side Effects

  • • Liver dysfunctions
  • • Cardiovascular complications
  • • Kidney dysfunctions
  • • Electrolyte imbalance
  • • Severe dehydration
  • • Lung toxicity – cough, breathing difficulty
  • • Blurred vision

Precautions

To be used cautiously in patients with:

  • • Kidney dysfunctions
  • • Liver dysfunctions
  • • Hypertension
  • • Eye issues
  • • Heart disorders
  • • Elderly patients
  • • Dehydration or on diuretics
  • • With diuretics and an EGFR inhibitor

Contraindications

Not to be used in patients-

  • • Hypersensitivity or allergy to the drug composition.
  • • Pregnant or breastfeeding women

Warnings

Prescription drug to be used under medical supervision.

Important Safety and Monitoring Information

  • • Blood pressure
  • • Liver functions
  • • Kidney functions
  • • Lung functions
  • • Skin irritation or rashes
  • • Signs of dehydration

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