Bleomycin

Bleomycin

Classification - Anticancer medicine

What is Bleomycin?

It is an anticancer medicine derived from a bacterium and is widely used for solid tumors and various cancers of the head and neck.

Uses of Bleomycin

Squamous tissue Carcinomas - head, neck, penis, uvula

Hodgkin's lymphoma

Non-Hodgkin's lymphoma

Pleural Effusion,Malignant

Testicular Carcinoma

How does it work?

It breaks the DNA strands, inhibiting their replication or multiplication

Common side effects

fever and chills

Mouth ulcers

Skin rashes

GIT upset

Hair loss

Tiredness

Reduced appetite

Serious side effects

Bone marrow suppression

Liver toxicity

Severe skin peeling, ulceration

Scarring of lung tissue

Pulmonary toxicity -shortness of breath,

Allergic reaction - difficulty breathing, skin flare

Precautions:

To be cautiously used in -

Pre-existing respiratory disorders

Smoking

Elderly patients

Heart problems

Kidney impairment

Undergoing surgery

Concurrent radiation therapy

Contraindications

Not to be used in patients-

Hypersensitivity to bleomycin

Pregnant and breastfeeding women

Warnings

Prescription drug to be used under medical supervision.

Important safety and monitoring information

Respiratory functions

Liver functions

Kidney functions

Blood count

Local necrosis

Storage

Store at 2-8 degrees Celsius,

Protected from light.

Administration Instructions

To be administered as a slow IV infusion over 15-60 minutes.

Globally prescribed bleomycin formulation - Bleokey

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