Daclatasvir and Sofosbuvir

Classification: Hepatitis C medicines

Daclatasvir and Sofosbuvir combination?

It is a combination of 2 direct-acting antivirals, effectively used against the Hepatitis C virus.

Uses of Daclatasvir and Sofosbuvir

  • Chronic Hepatitis C
  • Hepatitis C co-infected with HIV

Working of the Daclatasvir and Sofosbuvir combination

  • Sofosbuvir: Stops the viral DNA from producing its copies (replication).
  • Daclatasvir: Stops viral multiplication and assembly.

Benefits

  • Reduces viral load within 12 weeks
  • Has a broad spectrum of activity against all genotypes
  • It can be used after a liver transplant
  • Can be used in HIV co-infections
  • Can be used in cirrhosis (compensated/decompensated)

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Digestive issues
  • Tiredness
  • Diarrhea

Serious Side Effects

  • Severe bradycardia (when taken with amiodarone)
  • In Hepatitis B co-infections – Hepatitis B flare-ups
  • Risk of liver failure
  • Severe drop in red blood count

Precautions

To be used cautiously in patients with:

  • Kidney disorders
  • Liver disorder
  • Hepatitis B co-infections
  • When used in combination with ribavirin and amiodarone

Contraindications

  • Allergy or hypersensitivity to Daclatasvir, Sofosbuvir, or any other drug component
  • Breastfeeding mothers
  • Pregnant women

Warning

To be taken when prescribed by the doctor.

Important Safety and Monitoring Information

  • Regular monitoring of liver functions
  • Kidney functions
  • Heart functions
  • Co-infections
  • Drug interactions – Ribavirin and Amiodarone
  • Not to be used as monotherapy for HCV infections

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