Domperidone + Esomeprazole

Classification: Acid reflux medicine

What is Esomeprazole ER & Domperidone SR?

It is a combination of 2 medicines.

Esomeprazole is added as an extended-release dose.

Domperidone is added in sustained-release form.

Esomeprazole ER & Domperidone SR uses

It is widely used in –

• Gastric acid reflux
• GERD
• Indigestion
• Bloating
• Heartburn
• Nausea and vomiting

Esomeprazole ER & Domperidone SR side effects

• Dry mouth
• Headache
• Diarrhea /constipation
• Stomach pain
• Dizziness
• Drowsiness

Serious side effects

• Irregular heartbeat
• Severe diarrhea
• Allergic reaction
• Muscle tremors
• Muscle twitches

Long-term risks/side effects

Using it for a long duration leads to –

• Hypomagnesaemia
• Bone fractures
• Stomach infections
• Vitamin B12 deficiency

Precautions to be maintained with Esomeprazole ER & Domperidone SR capsule

The long-term use of esomeprazole /domperidone reduce gut absorption.

It leads to magnesium /calcium deficiency.

Do not drive, since it causes sleepiness.

Drinking alcohol worsens stomach acid.

What are Esomeprazole ER & Domperidone SR warnings?

Do not use it in conditions of –

• Severe organ failure
• Active stomach ulcers
• Mechanical blockage
• Electrolyte imbalance
• Pituitary tumor

The functions to be monitored for

• Heart functions
• Liver /kidney functions
• Electrolyte balance
• Vitamin B-12 levels
• Bone mineral density
• Prolactin levels

Drugs to be avoided with Esomeprazole ER & Domperidone SR

The PPIs reduce drug absorption and block metabolic enzymes.

Certain combinations may lead to –

• Reduced efficacy: Esomeprazole reduces drug absorption. Avoid its use with Clopidogrel, Antifungals, Antivirals, and Heart failure medications.
• Increased toxicity: Esomeprazole reduces drug clearance; it slows down drug metabolism. Avoid with Anti-seizure medicines, Immunosuppressants, and Warfarin.
• Cardiac toxicity: Domperidone leads to QT prolongation. It must be strictly avoided with cardio-toxic drugs such as HIV medicines and Antipsychotics.
• GIT side effects: Increased risk with anticholinergic and opioid drugs.

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