Hydroxyurea 500 Mg

Classification: Anticancer Medicine

Hydroxyurea?

An oncology treatment widely used for blood cancer, bone marrow cancer, and various solid tumors.

Uses of Hydroxyurea

  • • Resistant Chronic Myeloid Leukemia
  • • Melanoma
  • • Recurrent and Metastatic Carcinoma of the Ovary
  • • Head and neck cancer
  • • Sickle cell anemia
  • • Thrombocythemia

Working of Hydroxyurea

  • • Inhibits cancer enzymes causing cell growth
  • • Inhibits DNA synthesis
  • • Causes apoptosis and cancer cell death

Common Side Effects

  • • Nausea
  • • Vomiting
  • • Thrombopenia
  • • Fatigue
  • • Neutropenia

Serious Side Effects

  • • Bone marrow suppression
  • • Infection risk
  • • Skin inflammation and rashes
  • • Risk of secondary malignancies
  • • Liver dysfunctions
  • • Kidney dysfunctions

Contraindications

  • • Not to be used in patients with prior hypersensitivity to the drug or its excipients.
  • • Breastfeeding mothers
  • • Pregnant women

Precautions

To be cautiously used in:

  • • Renal insufficient patients
  • • Bleeding disorders
  • • Liver disorders
  • • Kidney disorders
  • • Immune-compromised individuals
  • • In combination with radiation therapy
  • • Chronic ulcers

Toxicities

  • • Hydroxyurea causes dose-dependent systemic toxicities.
  • • Bone marrow suppression causing thrombocytopenia, leukopenia
  • • Oral ulcers and mucositis
  • • Shortness of breath, cough, pulmonary fibrosis
  • • Hyperpigmentation and skin ulcers

Warnings

It is a prescription drug to be used under medical supervision only.

Important Safety and Monitoring Information

Hydroxyurea is generally well tolerated, but requires regular monitoring for:

  • • Blood functions
  • • Infections
  • • Kidney functions
  • • Skin changes
  • • Liver functions

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Aprahydro – A widely prescribed and trusted formulation for advanced blood cancer.