Ketoconazole 200 Mg

Classification: Antifungal Medicine

Ketoconazole- 200 mg?

It is used for various systemic fungal infections and yeast infections.

Uses

  • • Systemic fungal infections
  • • Mucocutaneous candidiasis
  • • Tinea infections
  • • Dermatitis
  • • Deep-seated fungal infections
  • • Psoriasis, caused by a fungal infection

Working of Ketoconazole

  • • Breaks the fungal cell membrane integrity.
  • • Causes fungal cell death.

Common Side Effects

  • • Nausea
  • • Vomiting
  • • Diarrhea
  • • Fatigue
  • • Stomach ache

Severe Side Effects

  • • Painful skin rashes
  • • Menstrual irregularities
  • • Gynecomastia
  • • Sexual dysfunction
  • • Arrhythmia
  • • Suppression of the adrenal glands
  • • Liver dysfunction
  • • Jaundice
  • • Electrolyte imbalance

Toxicities

  • • Liver toxicity
  • • Adrenal insufficiency
  • • Arrhythmia
  • • QT prolongation

Precautions

To be used cautiously in patients with

  • • Any heart problem
  • • Liver disorders
  • • Alcohol abuse
  • • Achlorhydra

Contraindications

Not to be used in patients –

  • • Hypersensitive or allergic to the drug composition.
  • • Breastfeeding mothers
  • • Pregnant women

Warning

To be used under medical prescription only

Important Safety and Monitoring Information

Regularly monitor –

  • • Liver function
  • • Heart rhythms
  • • Hormonal functions

Drug Interactions

Ketoconazole should be used with extreme caution with

  • • Cholesterol medicines – statins, fibrates
  • • Anticoagulants – Warfarin, Heparins
  • • Cardiovascular drugs – beta blockers, calcium channel blocker
  • • Antihypertensive – diuretics, ACE inhibitors
  • • Immunosuppressants – corticosteroids
  • • HIV – DDA
  • • Antipsychotics – antidepressants

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