Lamivudine + Zidovudine

Lamivudine (150mg) + Zidovudine (300mg)

Classification -HIV medicine

Lamivudine and Zidovudine?

The fixed doses of lamivudine and zidovudine form a highly active antiretroviral therapy against HIV.

Uses -

HIV infection

Post-exposure prophylaxis

To prevent HIV transmission to the child during pregnancy

Working of the lamivudine and zidovudine combination

It inhibits the multiplication of HIV cells

Reduces HIV cell count

Benefits

Reduces viral load

Improves immunity

Delays disease progression

Reduces the risk of transmission

Reduces co-infections

Increases CD4+ count

Can be used in children

Common side effects

Nasal congestion

Cough

Headache

Stomach pain

Indigestion- diarrhea, nausea

Tiredness

Muscle pain, joint pain

Sore throat

Serious side effects

Bone marrow suppression

Hepatomegaly - jaundice, yellowish urine

Lactic acidosis - breathing problems

Liver inflammation

Inflammation of the pancreas in children

Risk of severe infections

Allergic Reaction

Myopathy

Precautions

To be used cautiously in -

Liver diseases

Kidney impairment

Co-infections Hepatitis b

Pregnant and lactating women

Contraindications

Allergy to drug components

Severe liver dysfunction.

Bleeding disorders

Low platelet count

Alcohol abuse

Warnings

To be used under medical prescription.

Discontinuing immediately in Hepatitis B patients may cause serious hepatitis flare-ups.

Should not be used as monotherapy for HIV treatment

Important Monitoring Considerations

Check for -

Lactic acidosis

Liver function - elevated liver enzymes

Viral loads (HIV, HBV)

Pancreatitis

Check for co-infections

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