Mycophenolic Acid

Mycophenolic acid

Classification:

Organ Transplant Medicine

Mycophenolic Acid?

It is immune-suppressant medicine to reduce the organ rejection during transplant.

Mycophenolic acid oral uses -

Prophylaxis for organ transplant. Post-transplant therapy - Kidney transplant Liver transplant Heart transplant Autoimmune diseases- Psoriasis, SLE (off-label)

Working of Mycophenolic Acid?

It down-regulates the activity of B cells and T cells. Suppress the immune system. Helps prevent rejection of the new organ when transplanted in the body. Reduces anaphylactic immune response.

Common side effects

Skin rashes Risk of infection Low blood count Low platelets Anemia

Serious side effects

Risk of severe infection Bleeding - gastrointestinal perforation and bleeding Inflammation in the colon Risk of cancers, lymphomas, and skin cancers Risk of brain infection

Benefits:

More selective action, target immune cells. Do not harm other cells. Reduces the need for steroids Minimizes the risk of rejection Maintain immune tolerance Supports long-term graft survival

Precautions:

To be used cautiously in Kidney impairment Bleeding disorders Active infection Underline cancer Leukemia Elderly patients

Safety instructions

Maintain contraception during the treatment. Due to a compromised immune system avoid taking live medicines.

Contraindications

Should not be used in pregnant women and breastfeeding mothers. Hypersensitivity or allergy to drug components.

Warnings

To be used under medical prescription. Drug Interactions Antiviral Antacids Antibiotics And other immune suppressants

Important Monitoring Considerations

Monitor for - Total blood count Liver and kidney functions

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