Mycophenolic Acid

Classification: Organ Transplant Medicine

Mycophenolic Acid?

It is immune-suppressant medicine to reduce the organ rejection during transplant.

Mycophenolic Acid Oral Uses

  • • Prophylaxis for organ transplant.
  • • Post-transplant therapy – Kidney transplant, Liver transplant, Heart transplant
  • • Autoimmune diseases- Psoriasis, SLE (off-label)

Working of Mycophenolic Acid?

  • • It down-regulates the activity of B cells and T cells.
  • • Suppress the immune system.
  • • Helps prevent rejection of the new organ when transplanted in the body.
  • • Reduces anaphylactic immune response.

Common Side Effects

  • • Skin rashes
  • • Risk of infection
  • • Low blood count
  • • Low platelets
  • • Anemia

Serious Side Effects

  • • Risk of severe infection
  • • Bleeding – gastrointestinal perforation and bleeding
  • • Inflammation in the colon
  • • Risk of cancers, lymphomas, and skin cancers
  • • Risk of brain infection

Benefits

  • • More selective action, target immune cells.
  • • Do not harm other cells.
  • • Reduces the need for steroids
  • • Minimizes the risk of rejection
  • • Maintain immune tolerance
  • • Supports long-term graft survival

Precautions

To be used cautiously in

  • • Kidney impairment
  • • Bleeding disorders
  • • Active infection
  • • Underline cancer
  • • Leukemia
  • • Elderly patients

Safety Instructions

  • • Maintain contraception during the treatment.
  • • Avoid live vaccines (MMR, Varicella) due to a compromised immune system.

Contraindications

  • • Should not be used in pregnant women and breastfeeding mothers.
  • • Hypersensitivity or allergy to drug components.

Warnings

To be used under medical prescription.

Drug Interactions

  • • Antiviral
  • • Antacids
  • • Antibiotics
  • • And other immune suppressants

Important Monitoring Considerations

Monitor for –

  • • Total blood count
  • • Liver and kidney functions

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