Pazopanib
Classification: Anticancer
What is Pazopanib?
Pazopanib is an anticancer agent used against renal cancers and soft tissue sarcomas.
Best-selling formulation: Pazokast
Uses of Pazopanib
- • Renal cell carcinoma
- • Advanced Tissue Sarcoma
Working of Pazopanib
- • Multiple Tyrosine Kinase Inhibitors
- • It inhibits various growth factors for cancer cell growth.
- • Like – vascular endothelial growth factors, platelet-driven growth factors, etc.
Common Side Effects
- • Skin rashes
- • Breathing troubles
- • Changes in hair color, taste
- • Diarrhea
- • Loss of appetite
- • Weight loss
- • Tiredness
- • Irregular heartbeat
- • Dizziness
- • Blurred vision
Serious Side Effects
- • Gastrointestinal bleeding and perforation
- • Bleeding in urine and stool
- • QT prolongation
- • Chest pain
- • Heart failure
- • Jaundice – yellow eyes, urine
- • Stroke
- • Blood clots
- • Seizures, confusion
Precautions
To be used cautiously in patients with:
- • Liver disorders
- • High blood pressure
- • Bleeding disorders
- • Cardiac disorders – irregular heartbeats, stroke
Contraindications
- • Allergy or hypersensitivity to drug components
- • Breastfeeding mothers
- • Pregnant women
Warnings
To be used under medical prescription only.
Safety and Monitoring Information
Monitor –
- • Cardiac functions – ECG
- • High blood pressure
- • Elevated liver enzymes
- • Blood count
Drug Interactions
Anti-hypertensive, Antifungal, Anticoagulants, Warfarin, and antiviral drugs
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