Pazopanib

Classification: Anticancer

What is Pazopanib?

Pazopanib is an anticancer agent used against renal cancers and soft tissue sarcomas.

Best-selling formulation: Pazokast

Uses of Pazopanib

  • • Renal cell carcinoma
  • • Advanced Tissue Sarcoma

Working of Pazopanib

  • • Multiple Tyrosine Kinase Inhibitors
  • • It inhibits various growth factors for cancer cell growth.
  • • Like – vascular endothelial growth factors, platelet-driven growth factors, etc.

Common Side Effects

  • • Skin rashes
  • • Breathing troubles
  • • Changes in hair color, taste
  • • Diarrhea
  • • Loss of appetite
  • • Weight loss
  • • Tiredness
  • • Irregular heartbeat
  • • Dizziness
  • • Blurred vision

Serious Side Effects

  • • Gastrointestinal bleeding and perforation
  • • Bleeding in urine and stool
  • • QT prolongation
  • • Chest pain
  • • Heart failure
  • • Jaundice – yellow eyes, urine
  • • Stroke
  • • Blood clots
  • • Seizures, confusion

Precautions

To be used cautiously in patients with:

  • • Liver disorders
  • • High blood pressure
  • • Bleeding disorders
  • • Cardiac disorders – irregular heartbeats, stroke

Contraindications

  • • Allergy or hypersensitivity to drug components
  • • Breastfeeding mothers
  • • Pregnant women

Warnings

To be used under medical prescription only.

Safety and Monitoring Information

Monitor –

  • • Cardiac functions – ECG
  • • High blood pressure
  • • Elevated liver enzymes
  • • Blood count

Drug Interactions

Anti-hypertensive, Antifungal, Anticoagulants, Warfarin, and antiviral drugs

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