Temozolomide-100 mg
Classification – Anticancer
What is Temozolomide?
Temozolomide is an anticancer medicine used for various malignancies of the brain.
The best prescribed temozolomide – Temzokey
Uses of Temozolomide
- • Glioblastoma multiform
- • Anaplastic astrocytoma
- • Newly developed brain tumors
- • Recurrent brain tumors
- • Maintenance therapy to inhibit the progression of cancer
Working of Temozolomide
It alkylates DNA bases, breaking the cell integrity.
Causes cancer cell death.
Common side effects
- • Tiredness
- • Diarrhea
- • Nausea
- • Absence of periods in women
- • Risk of infections
- • Cough
- • Headache
- • Anemia
- • Hair loss
Serious side effects
- • Bone marrow depression
- • Bleeding in urine, stool
- • Severe infections
- • Increased liver enzymes
- • Cognitive dysfunction – confusion, seizures
- • Electrolyte imbalance
- • Risk of secondary malignancies – Acute myeloid leukemia or MSD
Precautions
To be used cautiously in patients with:
- • Secondary malignancies – MSD or acute myeloid leukemia
- • Liver disorders
- • Kidney disorder
- • Bleeding disorders
- • Immune-compromised patients
- • Use of any myelosuppressive treatment
- • Elderly
- • Children
Contraindications
- • Allergy or hypersensitivity to temozolomide or other drug components
- • Breastfeeding mothers
- • Pregnant women
Warning
To be used under medical prescription only.
Safety and monitoring information
Regular monitoring of –
- • Liver functions
- • Neurological condition – seizures, confusion
- • Hematologic profile – CBC
- • Opportunistic infections
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