Temozolomide

Classification - Anticancer

What is Temozolomide?

Temozolomide is an anticancer medicine used for various malignancies of the brain.

The best prescribed temozolomide - Temzokey

Uses of Temozolomide

Glioblastoma multiform

Anaplastic astrocytoma

Newly developed brain tumors

Recurrent brain tumors

Maintenance therapy to inhibit the progression of cancer.

Working of Temozolomide-

It alkylates DNA bases, breaking the cell integrity.

Causes cancer cell death.

Common side effects

Tiredness

Diarrhea

Nausea

Absence of periods in women

Risk of infections

Cough

Headache

Anemia

Hair loss

Serious side effects

Bone marrow depression

Bleeding in urine, stool

Severe infections

Increased liver enzymes

Cognitive dysfunction - confusion, seizures

Electrolyte imbalance

Risk of secondary malignancies- Acute myeloid leukemia or MSD

Precautions

To be used cautiously in patients with

Secondary malignancies - MSD or acute myeloid leukemia

Liver disorders

Kidney disorder

Bleeding disorders

Immune-compromised patients

Use of any myelosuppressive treatment

Elderly

Children

Contraindications

Allergy or hypersensitivity to temozolomide or other drug components.

Breastfeeding mothers

Pregnant women

Warning

To be used under medical prescription only.

Safety and monitoring information

Regular monitoring of -

Liver functions

Neurological condition- seizures, confusion

Hematologic profile- CBC

Opportunistic infections

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