The last stage of kidney disorder is where the functionality of the kidneys drops completely.
It is an irreversible condition causing liver failure.

How does kidney failure occur?

A gradual decline in kidney function characterizes it, but it may also be sudden.

Sudden Onset

When the kidney functions fall abruptly due to an infection, an adverse drug reaction, a progressive kidney disease, or an autoimmune disorder.
Within days, if not treated immediately, it leads to kidney failure.

Gradual Onset

The inflammation in the kidney that is extended long leads to a decline in kidney functionality.
The chronic diseases, like diabetes, hypertension, cause this inflammation.
Inflammation may also be caused by an injury to the nephrons.
Early onset is curable; however, prolonged inflammation is irreversible.

Understanding CKD and Progression to End-Stage Kidney Failure?

The inflammation in the kidney that persisted for a long duration causes CKD.
At the start, CKD does not give any indications, and when it persists for a long time, the kidney disease extends to irreversible damage.

Symptoms of End-Stage Kidney Disorder

Stages of CKD

There are five stages of CKD, from the asymptomatic stage to the advanced stage, which can cause kidney failure.
The CKD stages are represented by the Glomerular filtration rate.
Glomerular Filtration Rate – It is the amount of blood that the kidney filters per minute.
The normal GFR – 90 and 120 mL/min/1.73 m2.
A reduction in GFR indicates a kidney disorder.

• • Stage 1- The kidney functions may be normal.
  The GFR is normal (90 or higher).
  The damage has occurred, but it’s mild.
• • Stage 2- A mild decline in kidney function.
  The GFR is 60-89
• • Stage 3(a) – Mild to moderate decline in kidney function.
  The GFR is 45-59
• • Stage 3(b) – Moderate damage and decline in kidney function
  The GFR is 30-44
• • Stage 4 – It is the severe decline in kidney function.
  The GFR is 15-29
• • Stage 5- Zero functionality (kidney failure)
  The GFR is less than 15

The Potential Treatments for End-Stage Kidney Failure (Stage 5 CKD)

Dialysis

It is the immediate access to treatment after kidney failure.
It is the process of filtering blood externally through a machine or membrane.
It is a process that requires regular sessions, daily or weekly.

Types of Dialysis

There are two types of dialysis:

Hemodialysis
The process in which blood is taken out of the body through a vein and filtered through a dialyzer (machine) and then returned into the body.

Peritoneal Dialysis
The blood is filtered inside the body through the peritoneal membrane, and the catheter is surgically placed in the abdomen to infuse dialysate fluid into the body and facilitate fluid exchange.

Kidney Transplant

It is the replacement of the failed kidney with a healthy kidney from a donor.
Kidney transplant is a life-saving procedure, improves life quality and removes the need for dialysis.
The replaced kidney may be donated by a family member or a deceased person.
The kidney from a deceased person is used for individuals responding to dialysis and who are in stable condition.
The kidney from a living donor can be used in patients who have progressed to dialysis, and can be done before dialysis begins; it is called a pre-emptive transplant.
The kidney transplant as an option decided by the suitability of the person.

• • The overall physical well-being.
• • Availability of donor.
• • Willingness of the patient and acceptance of the risks involved.

Post-Kidney Transplant: The Most Crucial Commitment

The kidney transplant requires lifelong adherence to immunosuppressant or anti-rejection medications.

• • Mycophenolate- Mycocept 500, 250, 180 mg
• • Tacrolimus- X-Graf- 1.0, 0.5, and 2 mg

Conclusion

Kidney disorders are reversible when treated timely.
Dialysis and kidney transplant are the potential options for the last stage of kidney disease.
Dialysis offers a short-term treatment and is the immediate treatment; however, a transplant is a long-term treatment that demands a lifelong commitment to post-transplant care.