Fulvant (Fulvestrant Injection)

Fulvestrant

Classification - Anticancer Medicine

Fulvestrant?

It is an anticancer medicine widely used for breast cancer in post-menopausal women.

Uses -

HER-2 positive breast cancer

HER-2 negative breast cancer

Breast cancer that is resistant to endocrine therapy.

How does Fulvestrant work?

• Selective Estrogen Receptor Antagonist.
• It inhibits estrogen hormone, which causes cancer cells to grow.
• Stops cancer cell growth.
• Shrink the tumor.

Benefits

• As a preferred second-line option.
• Longer progression-free survival.
• Directly downregulate the receptor, offering complete blockade.
• Has better tolerance and a favorable safety profile.

Precautions -

Carefully administer to patients with -

• Blood disorders,
• Hypersensitive individuals,
• Hepatic impairment,
• Children, pregnant or lactating mothers.
• Elderly patients who are at risk of osteoporosis.
• Vitamin D or Calcium deficiency

Adverse drug effects

• Risk of bleeding,
• Sore throat,
• Mouth sores,
• Upset stomach,
• Nausea,
• Loss of appetite,
• Headache, and
• Tiredness.
• Flushing or redness of the skin at the site of injection.

Serious side effects -

• Hepatotoxicity - yellow coloration of urine, jaundice, hepatitis
• Pulmonary embolism, blood clots
• Severe necrosis
• Gastrointestinal perforation, bleeding
• Fracture or risk of bone demineralization

Important Safety and Monitoring Information

To monitor regularly during the therapy

• Total blood count
• Hepatic functions
• Kidney functions
• Local tissue necrosis
• Risks of bleeding
• Thromboembolic events

Contraindications -

Allergy or hypersensitivity to the drug components.

Breastfeeding mothers

Pregnant women

Warning:

To be used under medical supervision, an oncologist specialist.

Storage

It is to be stored at 2-8 degrees Celsius, protected from light.

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