Fulvestrant
Fulvestrant
Classification -
Anticancer Medicine
Fulvestrant?
It is an anticancer medicine widely used for breast cancer in post-menopausal women.
Uses -
HER-2 positive breast cancer HER-2 negative breast cancer Breast cancer that is resistant to endocrine therapy.
How does Fulvestrant work?
Selective Estrogen Receptor Antagonist. It inhibits estrogen hormone, which causes cancer cells to grow. Stops cancer cell growth. Shrink the tumor.
Benefits
As a preferred second-line option. Longer progression-free survival. Directly downregulate the receptor, offering complete blockade. Has better tolerance and a favorable safety profile.
Precautions -
Carefully administer to patients with - Blood disorders, Hypersensitive individuals, Hepatic impairment, Children, pregnant or lactating mothers. Elderly patients who are at risk of osteoporosis. Vitamin D or Calcium deficiency
Adverse drug effects
Risk of bleeding, Sore throat, Mouth sores, Upset stomach, Nausea, Loss of appetite, Headache, and Tiredness. Flushing or redness of the skin at the site of injection.
Serious side effects -
Hepatotoxicity - yellow coloration of urine, jaundice, hepatitis Pulmonary embolism, blood clots Severe necrosis Gastrointestinal perforation, bleeding Fracture or risk of bone demineralization
Important Safety and Monitoring Information
To monitor regularly during the therapy Total blood count Hepatic functions Kidney functions Local tissue necrosis Risks of bleeding Thromboembolic events
Contraindications -
Allergy or hypersensitivity to the drug components. Breastfeeding mothers Pregnant women
Warning:
To be used under medical supervision, an oncologist specialist.
Storage
It is to be stored at 2-8 degrees Celsius, protected from light.
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Formulations based on "Fulvestrant" (2)
Fulvant (Fulvestrant Injection)
Fulvestrant Injection
Product Name Fulvant Composition Fulvestrant Injection Dose/Strength 250 mg Form Injection Manufactured By Arechar Healthcare Prescription Required
Fulvekast 250mg Injection
Fulvestrant (250mg)
Product Name Fulvekast 250mg Injection Composition Fulvestrant 250mg Dose/Strength 250mg Form Injection Manufactured By Aprazer Healthcare Pvt Ltd Packaging Size 5 ml Prefilled Syringe Prescription Required Storage Store in a refrigerator (2 – 8°C). Do not freeze