Indenza (Enzalutamide 40 Mg)

Indenza 40 mg (Enzalutamide) is an androgen receptor (AR) inhibitor indicated for patients suffering from prostate cancer types such as,

• Metastatic castration-resistant prostate cancer where other chemotherapy options (docetaxel) did not work. (cancer that lowers the growth of testosterone, a male hormone)
• Metastatic castration-sensitive prostate cancer where other hormonal therapy did not work (cancer that spreads to other parts of the body)

Peculiar properties of Indenza 40 mg (Enzalutamide) that helps in slowing down the growth of prostate cancer,

• Obstructs the communication tool of cancer cells (AR signaling i.e. binding with androgen receptor and interaction with DNA)
• Hinders the unwanted growth (Cell proliferation) of androgen (testosterone)
• Induces the act of self-destruction of cells (Apoptosis)
• Reduces the risk of progression and death
• Postpones the requirement of chemotherapy

Administration of Indenza 40 mg (Enzalutamide):

Indenza 40 mg (Enzalutamide) is given orally in a 160 mg dosage (4×40 mg) once in 24 hours with or without food. If patients experience any sort of side-effects, the dosage can be modified and reduced to 120 mg (3×40 mg) or 80 mg (2×40 mg).

Once swallowed, enzalutamide is readily soluble (bio-available) in the body within 3 hours. It is metabolized in the liver and then distributed throughout the region of cancer with a high binding affinity (97%) to cancer cells. Once enzalutamide completes its activities, more than 50% of the dose is expelled from the body in between 3 to 11 days.

When should Indenza 40 mg (Enzalutamide) be avoided or used cautiously?

• • If patients have a history of or experience sudden unwarranted changes in behaviour caused due to disturbances in the brain (Seizures)
  • If patients are confirmed with symptoms like headache, impaired vision and low blood pressure (Posterior reversible encephalopathy syndrome)
  • If patients are seen with kidney diseases (severe renal impairment and end-stage renal disease)
  • If patients show signs of severe disease of the liver
  • If patients are seen with a relative risk of heart diseases
  • If patients are allergic to dosage and show symptoms like tongue, lip, or pharyngeal swelling (edema)
  • If patients are intolerant to lactose

Side-effects of Indenza 40 mg (Enzalutamide):

Most common side-effects:

• Tiredness (Fatigue)
• Pain in the back, muscles, bones and joints
• Diarrhea
• Weakness in the muscles
• Dizziness
• Swelling (edema) in the hands and legs
• Severe headache
• Cold-like symptoms
• Anxiety or stress

Other side-effects:

• Discoloured urine in pink or red colour (Hematuria)
• Rashes on skin
• Trouble in falling asleep (insomnia)
• Trouble in breathing (pneumonia)
• Weakness in the legs
• Pain in the lower back
• High blood pressure (Hypertension)
• Burning or numbness of skin (paresthesia)
• Excitement or confusion
• Loss of memory
• Nightmares

Note:

• These are not all possible side-effects of Indenza 40 mg (Enzalutamide), please ask your doctor for more information regarding the same.
• We are also exporting to countries: Malaysia, Indonesia, Philippines, Venezuela and Korea.