Enzalutamide

Classification: Anticancer Medicine

What is Enzalutamide?

It is a second-generation androgen receptor antagonist, widely used for advanced prostate cancer or resistant cancers that do not respond to hormone deprivation therapy.

Uses of Enzalutamide

  • • Castration Resistant Prostate Cancer
  • • Metastatic Castration Resistant Prostate Cancer
  • • Hormone-sensitive Castration Resistant Prostate Cancer

Working of Enzalutamide

  • • Enzalutamide blocks the androgen receptor on cancer cells.
  • • Inhibits the binding of testosterone that stimulates cancer growth
  • • Shrink cancer and slow down its growth.

Common Side Effects

  • • Dizziness
  • • Fatigue
  • • Muscle and joint pain
  • • Diarrhea
  • • Skin rashes and dryness
  • • Hot flushes

Serious Side Effects

Generally, dose-dependent side effects are seen:

  • • QT prolongation, hypertension
  • • Elevated liver enzymes
  • • Restless leg syndrome, seizures
  • • Bone fractures, weakness, pain
  • • Irregular heartbeats

Contraindications

  • • Not to be used if any previous allergy or hypersensitivity to Enzalutamide or any excipients.
  • • Not prescribed for women
  • • Breastfeeding mothers
  • • Pregnant women

Precautions

Cautiously to be used in patients with :

  • • Heart problems
  • • High cholesterol levels
  • • Diabetic people
  • • High blood pressure
  • • Brain injury or tumor

Warnings

To be used only under medical prescription.

Important Safety and Monitoring Information

  • • Regular monitoring of the liver function, cardiac rhythms, and bone density.

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