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Lapakast -250 mg

Lapakast -250 mg

Molecular Salt: Lapatinib Ditosylate

Lapakast -250 mg

Composition: Lapatinib Ditosylate IP -250mg

Therapeutic Class: Antineoplastic

What is Lapakast?

Lapakast is an anticancer medicine that is used orally against solid tumors and breast cancers.

Uses of Lapakast –

  • Advanced-stage Breast cancer
  • Metastatic Breast Cancer
  • Lung cancer

How does Lepakast work?

It causes programmed cell death by inhibiting HER-2 and EGFR receptors.

It inhibits signals for cancer cell growth and division.

Common Side-Effects

  • Anorexia
  • Diarrhea
  • Skin rashes, itchiness
  • Stomatitis, constipation, and abdominal pain
  • Palmar-plantar erythrodysaesthesia
  • Pain in the extremity, back pain
  • Hair loss

Serious Side-Effects

  • Bleeding in the stomach
  • Dehydration
  • Electrolyte imbalance
  • QT prolongation
  • Hand and foot syndrome

Toxicities

  • Cardiac toxicities
  • Hepatotoxicity
  • Interstitial Lung Disease
  • Pneumonitis

Contraindications

Not to be used in patients –

  • Hypersensitive or allergic to the drug or its excipients.
  • Breastfeeding mothers
  • Pregnant women

Precautions

To be used cautiously in patients with

  • Heart disease
  • Low blood count
  • Liver disease

Warnings

To be used under medical supervision

Important Safety and Monitoring Information

Regular monitoring is crucial for patient safety and treatment efficacy -

  • The liver function- AST, ALT, bilirubin, alkaline phosphatase
  • Cardiac function- periodic assessment of left ventricular ejection
  • Electrolyte balance- potassium, magnesium levels
  • GIT disturbances- hydration status
  • Regular blood count – Complete blood count
Manufacturer

Aprazer Healthcare

Dosage / Formulation

Tablets (250mg)

Packaging Size

Single Pack Unit

Storage Protocol

Store below 30°C

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Storage Warning: Biological injectables, biosimilars, and active oncology agents are flagged as temperature-sensitive cargo and are packed strictly inside thermal containers coupled with real-time digital temperature tags.