Sofokast (sofosbuvir) 400mg

Composition: Sofosbuvir - 400mg

Classification: Hepatitis C medicine

What is Sofokast?

An antiviral against HCV, used in combination for the treatment of Chronic Hepatitis C.

Uses of Sofokast

Chronic Hepatitis C

HCV-HIV confections

How does it work?

It inhibits the viral DNA synthesis, it is a prodrug which is activated in the liver.

Benefits

Can be used in-

Cirrhosis (compensated /decompensated).

HIV co-infections.

In children> 3 years

Post liver transplant

Effective across various HCV strains

Low resistance risk

Common Side Effects

Nausea,

Dizziness,

Headache,

Digestive issues,

Tiredness,

Diarrhea

Serious Side Effects

Bradycardia, when combined with Amiodarone

Hepatitis B flare-ups in co-infection.

Lowered red blood count when used with ribavirin

Liver failure occurs in advanced liver disorder.

Depression, mood swings, and confusion

Precautions

To be used cautiously in patients

Kidney disorders

Liver disorder

Hepatitis B co-infections- cause reactivation

HIV co-infection

When used in combination with ribavirin and amiodarone

Contraindications

Allergy or hypersensitivity to drug components.

Breastfeeding mothers

Pregnant women

Warning

To be used when prescribed by the doctor.

Not to be used as monotherapy for HCV infections.

Important Safety and Monitoring Information

Regularly monitor-

Hepatic functions,

Renal functions,

Cardiac functions,

Co-infections,

Neuropsychiatric functions

Drug interactions - Ribavarin and Amiodarone