Sofosbuvir
Classification - Hepatitis C Medicine
Sofosbuvir + Ledipasvir combination -
Trusted combination of antiviral drugs effective against Hepatitis C genotypes 1,4,5,6.
Can be used in cirrhosis (both compensated and decompensated).
Can be used in HIV co-infections.
In children> 3 years
Can be used post-liver transplant
Uses -
Chronic Hepatitis C
HCV-HIV co-infections
Working of Sofosbuvir and ledipasvir
It inhibits viral cell replication by inhibiting two different protein polymerases, offering potent viral suppression.
Benefits
Short-term treatment
High cure rates
Low resistance risk
Well tolerated
Reduces liver damage
Common Side Effects
Nausea, dizziness, headache, digestive issues, tiredness, muscle pain, joint pain
Serious Side Effects
Severe Bradycardia (when taken with amiodarone)
Causes Hepatitis B reactivation.
Severe liver failure.
Severe anemia upon use with ribavirin.
Depression, mood swings, and confusion
Precautions
To be used cautiously in patients
Kidney disorders
cardiac disorders
Liver disorder
Hepatitis B co-infections- cause reactivation
HIV co-infection
When used in combination with ribavirin and amiodarone
Contraindications
Allergy or hypersensitivity to drug components.
Breastfeeding mothers
Pregnant women
Should not be used with Amiodarone, Antacids, and proton pump inhibitors.
Warning
To be taken under the instructions of the doctor.
Important Safety and Monitoring Information
Regular monitoring of hepatic functions,
Renal functions,
Cardiac functions,
Co-infections, and
Neuropsychiatric adverse reactions.
Drug interactions - Ribavirin and Amiodarone
Not to be used alone for HCV infections.
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Formulations based on "Sofosbuvir" (20)
Sofokast (sofosbuvir) 400mg
Sofosbuvir
Product Name Sofokast 400 mg Dose/Strength 400 mg Packaging Size 28 Tablets
Sofovir
Sofosbuvir
Product Name Sofovir Composition Sofosbuvir Dose/Strength 400mg Packaging Size 28 Tablets Manufactured By Hetero Prescription Required Storage Store below 30°C
Ledifos
Sofosbuvir / Ledipasvir
Product Name Ledifos Dose/Strength 90MG/400MG Packaging Size 28 Tablets
Velasof
Sofosbuvir / Velpatasvir
Product Name Velasof Composition sofosbuvir 400mg + velpatasvir 100mg Manufactured By Hetero Healthcare Limited Dose/Strength 400 mg/ 100 mg Packaging Size 28 Tablets
LediHep
Sofosbuvir / Ledipasvir
Product Name LediHep Composition Ledipasvir + Sofosbuvir Dose/Strength 90MG/400MG Packaging Size 28 Tablets Manufactured By Zydus Prescription Required Storage Store below 30°C
SoviHep V
Sofosbuvir / Velpatasvir
Product Name SoviHep V Composition Sofosbuvir + Velpatasvir Dose/Strength 400MG/100MG Packaging Size 28 Tablets Manufactured By Zydus Prescription Required Storage Store below 30°C
Hepcinat
Sofosbuvir
Product Name Hepcinat Composition Sofosbuvir Dose/Strength 400 mg Packaging Size 28 Tablets Manufactured By NATCO Prescription Required Storage Store below 30°C
MyHep
Sofosbuvir
Product Name MyHep Composition Sofosbuvir Dose/Strength 400 mg Packaging Size 28 Tablets Manufactured By Mylan Prescription Required Storage Store below 30°C
Hepcinat LP
Sofosbuvir / Ledipasvir
Product Name Hepcinat LP Composition Ledipasvir + Sofosbuvir Dose/Strength 90 mg/400 mg Packaging Size 1×28 Tablets Manufactured By NATCO Prescription Required Storage Store below 30°C
MyHep DVIR
Sofosbuvir / Daclatasvir
Product Name MyHep VIR Dose/Strength 60mg+400 mg Form Tablet Composition Daclatasvir and sofosbuvir Manufactured By Mylan Packaging Size 28 Tablets Prescription Required
Velakast
Sofosbuvir / Velpatasvir
Product Name Velakast Composition sofosbuvir 400mg + velpatasvir 100mg Manufactured By Aprazer Healthcare Dose/Strength 400mg/100mg Packaging Size 28 Tablets Prescription Required Storage Store below 30°C
Ledikast
Sofosbuvir / Ledipasvir
Product Name Ledikast Composition Ledipasvir + Sofosbuvir Dose/Strength 400MG/90MG Packaging Size 28 Tablets Manufactured By Aprazer Healthcare Prescription Required Storage Store below 30°C
Sofokast Plus
Sofosbuvir / Daclatasvir
Product Name Sofokast Plus Composition Daclatasvir + Sofosbuvir Dose/Strength 60MG/400MG Packaging Size 28 Tablets Manufactured By Aprazer Healthcare Prescription Required Storage Store below 30°C
Sovihep
Sofosbuvir
Product Name SoviHep Composition Sofosbuvir Dose/Strength 400mg Packaging Size 28 Tablets Manufactured By Zydus Prescription Required Storage Store below 30°C
Velpanat
Sofosbuvir / Velpatasvir
Product Name Velpanat Composition Sofosbuvir + Velpatasvir Dose/Strength 400 mg Packaging Size 28 Tablets Manufactured By NATCO Prescription Required Storage Store below 30°C
Hepcinat Plus
Sofosbuvir / Daclatasvir
Product Name Hepcinat Plus Composition Daclatasvir + Sofosbuvir Dose/Strength 60MG/400MG Packaging Size 28 Tablets Manufactured By NATCO Prescription Required Storage Store below 30°C
MyHep LVIR
Sofosbuvir / Ledipasvir
Product Name MyHep LVIR Composition Ledipasvir + Sofosbuvir Dose/Strength 90mg+400 mg Packaging Size 28 Tablets Manufactured By Mylan Prescription Required Storage Store below 30°C
MyHep All
Sofosbuvir / Velpatasvir
Product Name MyHep All Composition sofosbuvir + velpatasvir Dose/Strength 400 mg/100 mg Packaging Size 28 Tablets Manufactured By Mylan Prescription Required Storage Store below 30°C
Hepcvel
Sofosbuvir / Velpatasvir
Product Name Hepcvel Composition Sofosbuvir 400mg + Velpatasvir 100mg Dose/Strength 400 mg + 90 mg Packaging Size 28 Tablet Manufactured By Cipla Prescription Required Storage Store below 30°C
Qurled
Sofosbuvir
Product Name Qurled Composition Sofosbuvir Dose/Strength 400 mg Packaging Size 28 Tablets Manufactured By Strides Pharma Prescription Required Storage Store below 30°C